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CENPE contributes to pulmonary vascular remodeling in pulmonary hypertension

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收录情况： ◇ SCIE

作者：

单位： [1]Huazhong Univ Sci & Technol,Dept Resp Dis,Tongji Hosp,Tongji Med Coll,Key Lab Pulm Dis,Hlth Minist,Key Site Natl Clin R,Wuhan 430000,Peoples R China

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关键词： CENPE Pulmonary hypertension CDK1 Pulmonary vascular remodeling

摘要：

Hypoxic pulmonary vascular remodeling is a pathological feature of pulmonary hypertension (PH). Our results showed that centromere-associated protein E (CENPE) expression in PH patients and hypoxiainduced PH rats was significantly higher than that in normal controls. In addition, CENPE deficiency significantly inhibited the development of pulmonary vascular remodeling and right ventricular hypertrophy. Moreover, knocking out CENPE effectively inhibited the proliferation and induced the apoptosis of primary pulmonary artery smooth muscle cells (PASMCs) in vivo. Furthermore, CENPE silencing by small interference significantly inhibited abnormal proliferation, apoptosis resistance, migration, and cell cycle arrest in hypoxia-induced PASMCs. Interestingly, we found that CENPE might exert its biological effect by targeting the transcription of CDK1 proteins. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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出版当年[2020]版：

大类 | 3 区生物

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

JCR分区：

出版当年[2019]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.985 出版当年[2019版] 2.75 出版当年五年平均 2.705 出版前一年[2018版] 3.575 出版后一年[2020版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol,Dept Resp Dis,Tongji Hosp,Tongji Med Coll,Key Lab Pulm Dis,Hlth Minist,Key Site Natl Clin R,Wuhan 430000,Peoples R China

通讯作者：

通讯机构： [1]Huazhong Univ Sci & Technol,Dept Resp Dis,Tongji Hosp,Tongji Med Coll,Key Lab Pulm Dis,Hlth Minist,Key Site Natl Clin R,Wuhan 430000,Peoples R China [*1]Huazhong Univ Sci & Technol,Dept Resp Dis,Tongji Hosp,Key Lab Pulm Dis,Hlth Minist,Tongji Med Coll,1095 Jiefang Ave,Wuhan 430000,Hubei,Peoples R China

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