KIAA1199, also known as CEMIP or HYBID, is an important member of the Human Unidentified Gene-Encoded (HUGE) database. Accumulated evidence has revealed that KIAA1199 is associated with tumor progression and metastasis in numerous malignancies, including colorectal, liver, gastric, pancreatic, breast, lung, prostate, ovarian and papillary thyroid cancers. As an oncogene, it plays crucial role in the proliferation, apoptosis, invasion and migration of various tumor cells. In addition, KIAA1199 is also involved in the regulation of multiple signal pathways such as epithelial-mesenchymal transition (EMT), Wnt/ ?-catenin, MEK/ERK and PI3K/Akt. In this review, we summarized up to date advancement on the role of KIAA1199 in human cancer development, progression, and metastasis. We also addressed KIAA1199 as a potential therapeutic target for cancer therapy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81800547, 81702396, 81772607]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区医学
小类|2 区药学3 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2019]版：
Q1PHARMACOLOGY & PHARMACYQ1MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Gastroenterol, Tongji Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Jingmei,Yan Wei,Han Ping,et al.The emerging role of KIAA1199 in cancer development and therapy[J].BIOMEDICINE & PHARMACOTHERAPY.2021,138:doi:10.1016/j.biopha.2021.111507.
APA：
Liu, Jingmei,Yan, Wei,Han, Ping&Tian, Dean.(2021).The emerging role of KIAA1199 in cancer development and therapy.BIOMEDICINE & PHARMACOTHERAPY,138,
MLA：
Liu, Jingmei,et al."The emerging role of KIAA1199 in cancer development and therapy".BIOMEDICINE & PHARMACOTHERAPY 138.(2021)
