PNO1 has been reported to be involved in tumorigenesis, however, its role in glioma remains unexplored. In the present study, PNO1 expression in glioma from on-line databases, cDNA, and tissue microarrays was upregulated and associated with poor prognosis. PNO1 knockdown inhibits tumor cell growth and invasion both in vitro and in vivo; whereas PNO1 overexpression promoted cell proliferation and invasion in vitro. Notably, PNO1 interacted with THBS1 and the promotion of glioma by PNO1 overexpression could be attenuated or even reversed by simultaneously silencing THBS1. Functionally, PNO1 was involved in activation of FAK/Akt pathway. Moreover, overexpressing MYC increased PNO1 promoter activity. MYC knockdown decreased PNO1 and THBS1 expression, while inhibited cell proliferation and invasion. In conclusion, MYC-mediated upregulation of PNO1 contributes to glioma progression by activating THBS1/FAK/Akt signaling. PNO1 was reported to be a tumor promotor in the development and progression of glioma and may act as a candidate of therapeutic target in glioma treatment.
基金：
State Scholarship Fund of China Scholarship CouncilChina Scholarship Council [20180851007, 201708515096]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Neurosurg,Tongji Med Coll,Jiefang Ave 1095,Wuhan 430030,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Xu,Guo Zheng-Qian,Cao Dan,et al.MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling[J].CELL DEATH & DISEASE.2021,12(3):doi:10.1038/s41419-021-03532-y.
APA：
Chen,Xu,Guo,Zheng-Qian,Cao,Dan,Chen,Yong&Chen,Jian.(2021).MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling.CELL DEATH & DISEASE,12,(3)
MLA：
Chen,Xu,et al."MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling".CELL DEATH & DISEASE 12..3(2021)
生物学