Nanoparticles are important mediators for cancer photothermal therapy (PTT) where they can efficiently convert photon energy into heat and ablate the surrounding cancer cells with superior spatial and temporal precision. Recent decades have witnessed a booming development of numerous formulations of PTT nanoparticles that exhibit outstanding anti-tumor efficacy in preclinical studies. However, their clinical translation has been mined by safety concerns, especially their long-term impact on human body. Biodegradable nanoparticles that can be excreted after PTT, therefore, are gaining popularity due to their biocompatibility and improved safety profiles. This chapter provides an update on the progress in clearable PTT nanoparticles for cancer treatment. We discuss their design, synthesis strategy, and physicochemical properties relevant to photothermal performance. We also review their biodistribution patterns and in vivo anti-tumor efficacy, along with their degradation mechanism and clearance kinetics. Lastly, we present a brief overview of the imaging techniques to noninvasively monitor the degradation of PTT nanoparticles.