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Hypoxia-induced lncRNA CASC9 enhances glycolysis and the epithelial-mesenchymal transition of pancreatic cancer by a positive feedback loop with AKT/HIF-1α signaling.

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收录情况： ◇ SCIE ◇ 预警期刊

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单位： [1]Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province,China [2]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Scienceand Technology,Wuhan 430022,Hubei Province,China [3]Department of Dermatology, Central Hospital of Wuhan,Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China [4]Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China [5]Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute and Hospital, NationalClinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China

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关键词： CASC9 HIF-1α AKT hypoxia glycolysis EMT pancreatic cancer

摘要：

Increasing evidence indicates the dysregulations and pivotal roles of lncRNAs in the development and progression of various cancers, including pancreatic cancer. Enhanced glycolytic flux and epithelial-to-mesenchymal transition (EMT) have been considered as important factors in driving the malignance of pancreatic cancer. Here, we sought to evaluate the biological role and involved mechanism of lncRNA CASC9 (CASC9) in pancreatic cancer. Our present study showed that CASC9 was upregulated in various pancreatic cancer cell lines. Loss- and gain-of function of CASC9 demonstrated its critical roles in promoting the glycolysis and EMT phenotypes of pancreatic cancer. Moreover, knockdown of CASC9 inhibited the tumorigenicity and metastasis in vivo. Additionally, our findings showed that hypoxia induced the expression of CASC9 and enhanced the binding of HIF-1α to its promoter. We also demonstrated that the positive feedback loop of CASC9 and the AKT/HIF-1α signaling cascade partially mediated this biological process. Altogether, our results suggest that CASC9 promotes the glycolysis and EMT of pancreatic cancer by a positive feedback loop with AKT/HIF-1α signaling, which is synergistically enhanced by the tumor hypoxic niche. Our study will provide potential therapeutic targets for treating pancreatic cancer. AJCR Copyright © 2021.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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出版当年[2019]版：

Q1 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.6 最新[2023版] 4.5 最新五年平均 5.177 出版当年[2019版] 4.725 出版当年五年平均 4.737 出版前一年[2018版] 6.166 出版后一年[2020版]

第一作者：

第一作者单位： [1]Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province,China

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通讯机构： [1]Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province,China [*1]Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China

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