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LncRNA influence sequential steps of hepatocellular carcinoma metastasis

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单位: [1]Huazhong Univ Sci & Technol,Hubei Key Lab Hepatopancreatobiliary Dis,Clin Med Res Ctr Hepat Surg Hubei Prov,Key Lab Or,Hepat Surg Ctr,Tongji Hosp,Tongji Med Coll,Minist,Wuhan 430030,Hubei,Peoples R China [2]Minist Publ Hlth, Wuhan 430030, Hubei, Peoples R China
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关键词: Hepatocellular carcinoma Long noncoding RNA Metastasis

摘要:
As a class of new and crucial molecules involved in the regulation of biological function, long noncoding RNA (lncRNA) have obtained widespread attention in recent days. While it was thought that lncRNA would be redundant in the past, it is proved that lncRNA identify a class of molecular that regulate the homeostasis including hepatocellular carcinoma in the present. All kinds of lncRNA have been implicated in a various of diseases, particularly in tumorigenesis and metastasis. But the mechanisms how they act is still not entirely clear. Metastasis is a major factor affecting long-term survival in hepatocellular carcinoma (HCC) patients. Recently, growing numbers of experiments demonstrate that there is close connection between lncRNA and HCC metastasis. Here, we will briefly introduce a series of steps (primary tumor growth, angiogenesis, epithelial-to-mesenchymal transition, invasion, intravasation, survival in circulatory system, extravasation, dormancy and subsequent secondary tumor growth) of tumor metastasis, its classical but promising theories, the role of lncRNA in metastasis and the possible mechanisms involved. LncRNA, as potentially new and important tumor diagnostic and therapeutic molecules, has attracted much attention in recent years.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 2 区 药学 3 区 医学:研究与实验
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 医学:研究与实验 2 区 药学
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出版当年[2019]版:
Q1 PHARMACOLOGY & PHARMACY Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者单位: [1]Huazhong Univ Sci & Technol,Hubei Key Lab Hepatopancreatobiliary Dis,Clin Med Res Ctr Hepat Surg Hubei Prov,Key Lab Or,Hepat Surg Ctr,Tongji Hosp,Tongji Med Coll,Minist,Wuhan 430030,Hubei,Peoples R China [2]Minist Publ Hlth, Wuhan 430030, Hubei, Peoples R China
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通讯机构: [1]Huazhong Univ Sci & Technol,Hubei Key Lab Hepatopancreatobiliary Dis,Clin Med Res Ctr Hepat Surg Hubei Prov,Key Lab Or,Hepat Surg Ctr,Tongji Hosp,Tongji Med Coll,Minist,Wuhan 430030,Hubei,Peoples R China [2]Minist Publ Hlth, Wuhan 430030, Hubei, Peoples R China
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