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Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes Among Normoglycemic Chinese Adults: Findings From the 4C Study

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收录情况： ◇ SCIE

作者：
Lu, Jieli[1,2] * ; Wang, Shuangyuan[1,2] ; Li, Mian[1,2] ; Gao, Zhengnan[3] ; Xu, Yu[1,2] ; Zhao, Xinjie[4] ; Hu, Chunyan[1,2] ; Zhang, Yi[1,2] ; Liu, Ruixin[1,2,5] ; Hu, Ruying[5] ; Shi, Lixin[6] ; Zheng, Ruizhi[1,2] ; Du, Rui[1,2] ; Su, Qing[7] ; Wang, Jiqiu[1,2] ; Chen, Yuhong[1,2] ; Yu, Xuefeng[8] ; Yan, Li[9] ; Wang, Tiange[1,2] ; Zhao, Zhiyun[1,2] ; Wang, Xiaolin[4] ; Li, Qi[4] ; Qin, Guijun[10] ; Wan, Qin[11] ; Chen, Gang[12] ; Xu, Min[1,2] ; Dai, Meng[1,2] ; Zhang, Di[1,2] ; Tang, Xulei[13] ; Wang, Guixia[14] ; Shen, Feixia[15] ; Luo, Zuojie[16] ; Qin, Yingfen[16] ; Chen, Li[17] ; Huo, Yanan[18] ; Li, Qiang[19] ; Ye, Zhen[5] ; Zhang, Yinfei[20] ; Liu, Chao[21] ; Wang, Youmin[22] ; Wu, Shengli[23] ; Yang, Tao[24] ; Deng, Huacong[25] ; Li, Donghui[26] ; Lai, Shenghan[27] ; Mu, Yiming[28] ; Chen, Lulu[29] ; Zhao, Jiajun[30] ; Xu, Guowang[4] ; Ning, Guang[1,2] ; Bi, Yufang[1] ; Wang, Weiqing[1,2] ;
单位： [1]Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis, Ruijin Hosp,Sch Med, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Key Lab Endocrine & Metab Dis Natl Hlth Commis PR, Shanghai Natl Ctr Translat Med,Ruijin Hosp,Sch M, Shanghai, Peoples R China [3]Dalian Municipal Cent Hosp, Dalian, Peoples R China [4]Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China [5]Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China [6]Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China [7]Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai, Peoples R China [8]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan, Peoples R China [9]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China [10]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China [11]Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China [12]Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China [13]Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China [14]Jilin Univ, Hosp 1, Changchun, Peoples R China [15]Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China [16]Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China [17]Shandong Univ, Qilu Hosp, Jinan, Peoples R China [18]Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China [19]Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China [20]Cent Hosp Shanghai Jiading Dist, Shanghai, Peoples R China [21]Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China [22]Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China [23]Karamay Municipal Peoples Hosp, Xinjiang, Peoples R China [24]Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China [25]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [26]Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA [27]Johns Hopkins Univ, Sch Med, Baltimore, MD USA [28]Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China [29]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan, Peoples R China [30]Shandong Univ, Shandong Prov Hosp, Jinan, Peoples R China
出处：
DOI： 10.2337/dc20-0884
ISSN：

摘要：
OBJECTIVE Comprehensive assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We examined the association of serum BA profile and coregulation with the risk of developing type 2 diabetes mellitus (T2DM) among normoglycemic Chinese adults. RESEARCH DESIGN AND METHODS We tested 23 serum BA species in subjects with incident diabetes (n = 1,707) and control subjects (n = 1,707) matched by propensity score (including age, sex, BMI, and fasting glucose) from the China Cardiometabolic Disease and Cancer Cohort (4C) Study, which was composed of 54,807 normoglycemic Chinese adults with a median follow-up of 3.03 years. Multivariable-adjusted odds ratios (ORs) for associations of BAs with T2DM were estimated using conditional logistic regression. RESULTS In multivariable-adjusted logistic regression analysis, per SD increment of unconjugated primary and secondary BAs were inversely associated with incident diabetes, with an OR (95% CI) of 0.89 (0.83-0.96) for cholic acid, 0.90 (0.84-0.97) for chenodeoxycholic acid, and 0.90 (0.83-0.96) for deoxycholic acid (P < 0.05 and false discovery rate <0.05). On the other hand, conjugated primary BAs (glycocholic acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, and sulfated glycochenodeoxycholic acid) and secondary BA (tauroursodeoxycholic acid) were positively related with incident diabetes, with ORs ranging from 1.11 to 1.19 (95% CIs ranging between 1.05 and 1.28). In a fully adjusted model additionally adjusted for liver enzymes, HDL cholesterol, diet, 2-h postload glucose, HOMA-insulin resistance, and waist circumference, the risk estimates were similar. Differential correlation network analysis revealed that perturbations in intraclass (i.e., primary and secondary) and interclass (i.e., unconjugated and conjugated) BA coregulation preexisted before diabetes onset. CONCLUSIONS These findings reveal novel changes in BAs exist before incident T2DM and support a potential role of BA metabolism in the pathogenesis of diabetes.

基金：
Ministry of Science and Technology of China [2016YFC1305600, 2016YFC1305202, 2016YFC1304904, 2016YFC0901200, 2017ZX09304007, 2018YFC1311800]; National Natural Science Foundation of China [81930021, 81970728, 81970691, 81670795, 81730023, 81621061]; Shanghai Outstanding Academic Leaders Plan [18XD1402500, 20XD1422800]; Clinical Research Plan of Shanghai Hospital Development Center [SHDC2020CR3064B]; Shanghai Science and Technology Committee [20Y11905100]; Shanghai Municipal Natural Science Foundation [18ZR1433100]; Shanghai Medical and Health Development Foundation
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 医学
小类 | 1 区 内分泌学与代谢
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 内分泌学与代谢
JCR分区：
出版当年[2019]版：
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者单位： [1]Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis, Ruijin Hosp,Sch Med, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Key Lab Endocrine & Metab Dis Natl Hlth Commis PR, Shanghai Natl Ctr Translat Med,Ruijin Hosp,Sch M, Shanghai, Peoples R China
通讯作者：
通讯机构： [1]Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis, Ruijin Hosp,Sch Med, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Key Lab Endocrine & Metab Dis Natl Hlth Commis PR, Shanghai Natl Ctr Translat Med,Ruijin Hosp,Sch M, Shanghai, Peoples R China
推荐引用方式(GB/T 7714)：
Lu Jieli,Wang Shuangyuan,Li Mian,et al.Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes Among Normoglycemic Chinese Adults: Findings From the 4C Study[J].DIABETES CARE.2021,44(2):499-510.doi:10.2337/dc20-0884.
APA：
Lu, Jieli,Wang, Shuangyuan,Li, Mian,Gao, Zhengnan,Xu, Yu...&Wang, Weiqing.(2021).Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes Among Normoglycemic Chinese Adults: Findings From the 4C Study.DIABETES CARE,44,(2)
MLA：
Lu, Jieli,et al."Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes Among Normoglycemic Chinese Adults: Findings From the 4C Study".DIABETES CARE 44..2(2021):499-510

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