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Posttranslational Modifications in Ferroptosis

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收录情况： ◇ SCIE ◇ EI

作者：

单位： [1]Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan 430030, China [3]NHC Key Laboratory of Organ Transplantation, Wuhan 430030, China [4]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China [5]Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

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Ferroptosis was first coined in 2012 to describe the form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. To date, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative diseases (e.g., Huntington's, Alzheimer's, and Parkinson's diseases), ischemia-reperfusion injury, and cardiovascular diseases. Previous studies have identified numerous targets involved in ferroptosis; for example, acyl-CoA synthetase long-chain family member 4 (ACSL4) and p53 induce while glutathione peroxidase 4 (GPX4) and apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also known as FSP1) inhibit ferroptosis. At least three major pathways (the glutathione-GPX4, FSP1-coenzyme Q(10) (CoQ(10)), and GTP cyclohydrolase-1- (GCH1-) tetrahydrobiopterin (BH4) pathways) have been identified to participate in ferroptosis regulation. Recent advances have also highlighted the crucial roles of posttranslational modifications (PTMs) of proteins in ferroptosis. Here, we summarize the recently discovered knowledge regarding the mechanisms underlying ferroptosis, particularly the roles of PTMs in ferroptosis regulation.

基金：

基金编号： 81974013 81700249 81873458 81873456 WJ2019Q043

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出版当年[2019]版：

大类 | 2 区生物

小类 | 3 区细胞生物学

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无

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出版当年[2018]版：

Q2 CELL BIOLOGY

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无

影响因子： 0 最新[2023版] 0 最新五年平均 4.868 出版当年[2018版] 5.392 出版当年五年平均 4.936 出版前一年[2017版] 5.076 出版后一年[2019版]

第一作者：

第一作者单位： [1]Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan 430030, China [3]NHC Key Laboratory of Organ Transplantation, Wuhan 430030, China [4]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China

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通讯作者：

通讯机构： [1]Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan 430030, China [3]NHC Key Laboratory of Organ Transplantation, Wuhan 430030, China [4]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China

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