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Safety of semi-depot house dust mite allergen extract in children and adolescents with allergic rhinitis and asthma

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xiang, Li[1] * ; Liu, Fengxia[2] ; Zhi, Lili[3] ; Jiang, Weihong[4] ; Liu, Changshan[5] ; Xie, Hua[6] ; Zhou, Xiaoqin[7] ; Sun, Yuemei[8] ; Zheng, Yuejie[9] ; Zhu, Rongfei[10] ; Tao, Zezhang[11] ; Xia, Wanmin[12] ; Lai, He[13] ; Wei, Qingyu[14] ; Cheng, Lei[15,16] ; Tang, Yu[17] ; Xu, Rui[18] ; Huang, Huijie[1] ; Zhou, Queena[19] ; Chang, Peter[20] ;
单位： [1]Beijing Childrens Hosp, Dept Allergy, Beijing 100045, Peoples R China [2]Weifang Peoples Hosp, Dept Allergy, Weifang 261200, Peoples R China [3]Cent Hosp Zibo, Dept Allergy, Zibo 255020, Peoples R China [4]Cent South Univ, Dept Otorhinolaryngol, Xiangya Hosp, Changsha 410008, Peoples R China [5]Tianjin Med Univ, Dept Pediat, Hosp 2, Tianjin 300211, Peoples R China [6]Northern Theater Command, Dept Resp, Gen Hosp, Shenyang 110015, Peoples R China [7]Hubei Prov Maternal & Child Hlth Hosp, Dept Pediat, Wuhan 430070, Peoples R China [8]Yantai Yuhuangding Hosp, Dept Allergy, Yantai 264000, Peoples R China [9]Shenzhen Childrens Hosp, Dept Resp, Shenzhen 518026, Peoples R China [10]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Allergy, Wuhan 430030, Peoples R China [11]Wuhan Univ, Dept Otorhinolaryngol, Renmin Hosp, Wuhan 430060, Peoples R China [12]Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Pediat Resp Med, Chengdu 611731, Peoples R China [13]Guangzhou Med Univ, Dept Allergy, Affiliated Hosp 2, Guangzhou 510260, Peoples R China [14]Gen Hosp Northern Theater Command, Dept Allergy, Shenyang 110003, Peoples R China [15]Nanjing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol & Clin Allergy Ctr, Nanjing 210029, Peoples R China [16]Nanjing Med Univ, Int Ctr Allergy Res, Nanjing 210029, Peoples R China [17]Zhengzhou Univ, Depnt Resp, Childrens Hosp, Zhengzhou 450018, Peoples R China [18]Sun Yat Sen Univ, Dept Allergy, Affiliated Hosp 1, Otorhinolaryngol Hosp, Guangzhou 510080, Peoples R China [19]Merck Serono Co Ltd, Med Affairs, Beijing 100016, Peoples R China [20]Merck Serono Co Ltd, Global Biostat, Epidemiol, Med Writing GBEM, Beijing 100016, Peoples R China
出处：
DOI： 10.2217/imt-2020-0232
ISSN：

关键词： adolescents allergic rhinitis asthma children house dust mite multicenter safety semi-depot allergen extract subcutaneous immunotherapy tolerability

摘要：
Tweetable abstract Semi-depot house dust mite allergen extract is safe and well tolerated in children and adolescents with allergic rhinitis and asthma. Aim: Multicenter study to investigate the safety of mite extract product Novo-Helisen Depot, Strengths 1 to 3 (NHD3), as subcutaneous immunotherapy (SCIT), in Chinese children and adolescents with allergic rhinitis (AR) and allergic asthma (AA). Patients & methods: We evaluated SCIT-related adverse events (AEs) during NHD3 14-week initial therapy in children (5-11 years) and adolescents (12-17 years) with perennial symptomatic AR and AA. Results: Among 3600 injections in 250 patients, 361/3600 (10.0%) injections caused SCIT-related AEs in 96/250 (38.4%) patients, 321/3600 injections (8.9%) caused local reactions in 89/250 (35.6%) and 40/3600 injections (1.1%) caused systemic reactions in 23/250 (9.2%). Conclusion: Initial SCIT treatment using NHD3 was safe and well tolerated in Chinese children and adolescents with AR and AA.

基金：
Merck Serono China Co. Ltd, an affiliate of Merck KGaA, Darmstadt, Germany
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 免疫学
JCR分区：
出版当年[2019]版：
Q3 IMMUNOLOGY
最新[2023]版：
Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者单位： [1]Beijing Childrens Hosp, Dept Allergy, Beijing 100045, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xiang Li,Liu Fengxia,Zhi Lili,et al.Safety of semi-depot house dust mite allergen extract in children and adolescents with allergic rhinitis and asthma[J].IMMUNOTHERAPY.2021,13(3):227-239.doi:10.2217/imt-2020-0232.
APA：
Xiang, Li,Liu, Fengxia,Zhi, Lili,Jiang, Weihong,Liu, Changshan...&Chang, Peter.(2021).Safety of semi-depot house dust mite allergen extract in children and adolescents with allergic rhinitis and asthma.IMMUNOTHERAPY,13,(3)
MLA：
Xiang, Li,et al."Safety of semi-depot house dust mite allergen extract in children and adolescents with allergic rhinitis and asthma".IMMUNOTHERAPY 13..3(2021):227-239

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