COVID-19 caused by SARS-COV-2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes (T2D) as a comorbidity. While attenuated mortality was observed with aggressive glucose control, it was unclear whether therapeutic regimens including insulin treatment were beneficial for patients with COVID-19 and T2D. This retrospective study investigated 689 patients with COVID-19 and T2D from a cohort of 3,305 cases from Wuhan, China. Unexpectedly, we found that insulin treatment for patients with COVID-19 and T2D was associated with a significant increase in mortality (27.2% versus 3.5%; adjusted HR, 5.38 [2.75-10.54]). Further analysis showed that insulin treatment was associated with enhanced systemic inflammation and aggravated injuries of vital organs. Therefore, insulin treatment for patients with COVID-19 and T2D should be used with caution.
基金：
Nature Science Foundation of China [81630010, 81790624, C-0052]; Ministry of Science and Technology of China [2020YFC0844500]; Major Projects of Technological Innovation of Hubei Province [2017ACA170]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Cardiol,Dept Internal Med, Wuhan 430030, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Cardiol,Dept Internal Med, Wuhan 430030, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Yu Bo,Li Chenze,Sun Yang,et al.Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes[J].CELL METABOLISM.2021,33(1):65-+.doi:10.1016/j.cmet.2020.11.014.
APA：
Yu, Bo,Li, Chenze,Sun, Yang&Wang, Dao Wen.(2021).Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes.CELL METABOLISM,33,(1)
MLA：
Yu, Bo,et al."Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes".CELL METABOLISM 33..1(2021):65-+
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