A Model Using Support Vector Machines Recursive Feature Elimination (SVM-RFE) Algorithm to Classify Whether COPD Patients Have Been Continuously Managed According to GOLD Guidelines
单位:[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Resp & Crit Care Med,Wuhan,Peoples R China内科学系呼吸内科华中科技大学同济医学院附属同济医院[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Wuhan Clin Med Res Ctr Chron Airway Dis,Wuhan,Peoples R China华中科技大学同济医学院附属同济医院[3]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Key Lab Pulm Dis,Hlth Minist,Wuhan,Peoples R China华中科技大学同济医学院附属同济医院内科学系呼吸与危重症医学科[4]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Key Site Natl Clin Res Ctr Resp Dis,Wuhan,Peoples R China华中科技大学同济医学院附属同济医院内科学系呼吸与危重症医学科[5]Peking Univ Third Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China[6]Guilin Med Univ, Lab Resp Dis, Affiliated Hosp, Guilin, Peoples R China
Purpose: Patients with chronic obstructive pulmonary disease (COPD) would have a poor prognosis if they were not continuously managed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. We aim to develop a model to classify whether COPD patients have been continuously managed according to GOLD in the previous year. Methods: The Managed group were COPD patients from a prospective cohort from November 2017 to November 2019, who have been continuously managed according to GOLD for 1 year. The Control group were COPD patients who were not continuously managed according to GOLD. They were from a retrospective cohort from October 2016 to October 2017 in the same hospitals as the Managed group. A synthetic minority over-sampling technique (SMOTE) algorithm was used to up-sample the Managed group in a training dataset. Features for classification were selected using a support vector machine recursive feature elimination (SVM-RFE) algorithm. The classification model was developed using LibSVM, and its performance was assessed on the testing dataset. Results: The final analysis included 15 subjects in the Managed group and 191 in the Control group. SVM-RFE selects nine features including smoking history, post-bronchodilator (post-)FVC before management, and those after 1-year follow-up (BMI, moderate and severe AECOPD frequency in previous 12 months, mMRC score, post-FEV1, post-FEV1%pred, post-FVC, and post-FEV1/FVC). For our model, positive predictive value is 66.7%, F1 score is 0.978, and AUC is 0.987. Conclusion: SVM classifier combined with SVM-REF feature selection algorithm could achieve good classification between COPD patients who are or are not continuously managed. This model could be applied in clinical practice to help doctors make decisions and enhance COPD patients' compliance with standard treatment.
基金:
National Key Technologies RD Program [2016YFC1304700, 1303900]; National Natural Science Foundation of China [81700042]
第一作者单位:[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Resp & Crit Care Med,Wuhan,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Wuhan Clin Med Res Ctr Chron Airway Dis,Wuhan,Peoples R China[3]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Key Lab Pulm Dis,Hlth Minist,Wuhan,Peoples R China[4]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Key Site Natl Clin Res Ctr Resp Dis,Wuhan,Peoples R China
通讯作者:
通讯机构:[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Resp & Crit Care Med,Wuhan,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Wuhan Clin Med Res Ctr Chron Airway Dis,Wuhan,Peoples R China[3]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Key Lab Pulm Dis,Hlth Minist,Wuhan,Peoples R China[4]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Key Site Natl Clin Res Ctr Resp Dis,Wuhan,Peoples R China[6]Guilin Med Univ, Lab Resp Dis, Affiliated Hosp, Guilin, Peoples R China
推荐引用方式(GB/T 7714):
Xia Jie,Sun Lina,Xu Suqin,et al.A Model Using Support Vector Machines Recursive Feature Elimination (SVM-RFE) Algorithm to Classify Whether COPD Patients Have Been Continuously Managed According to GOLD Guidelines[J].INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.2020,15:2779-2786.doi:10.2147/COPD.S271237.
APA:
Xia, Jie,Sun, Lina,Xu, Suqin,Xiang, Qiu,Zhao, Jianping...&Chu, Shuyuan.(2020).A Model Using Support Vector Machines Recursive Feature Elimination (SVM-RFE) Algorithm to Classify Whether COPD Patients Have Been Continuously Managed According to GOLD Guidelines.INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,15,
MLA:
Xia, Jie,et al."A Model Using Support Vector Machines Recursive Feature Elimination (SVM-RFE) Algorithm to Classify Whether COPD Patients Have Been Continuously Managed According to GOLD Guidelines".INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 15.(2020):2779-2786