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Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway.

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资源类型：
Pubmed体系：
作者：
Yi Huang[1] * ; Jinli Wang[1] ; Mandi Luo[1] ; Dan Yan[1] ; Cuntai Zhang[1,*1] ;
单位： [1]Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1002/agm2.12125

关键词： calcification carnosine vascular smooth muscle cells

摘要：
Vascular calcification is prevalent in the aging population, as we know that arterial calcification is associated with aging. Recent studies have demonstrated that carnosine, a naturally occurring dipeptide, performs the treatment of aging-related diseases, such as atherosclerosis and type 2 diabetes. Here, we investigated the role of carnosine in a calcification model of vascular smooth muscle cells (VSMCs). In this research, we used an in vitro model of VSMC calcification to investigate the role of carnosine in the progression of rat VSMC calcification. Carnosine treatment attenuated calcium deposition in a dose-dependent manner, detected by Alizarin Red S staining and calcium content assay. Carnosine also reduced the protein level of Runx2, bone morphogenetic protein 2 (BMP-2), and cellular reactive oxygen species (ROS) production. Further, carnosine inhibited the activation of the mammalian target of rapamycin (mTOR) pathway. Carnosine attenuated the VSMC calcification via inhibition of osteoblastic transdifferentiation and the mTOR signaling pathway. © 2020 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd.

基金：
Natural Science Foundation of China (NSFC), Grant/Award Number: 81571377 and 81873811
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
无
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 老年医学
第一作者：
第一作者单位： [1]Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
通讯作者：
通讯机构： [1]Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [*1]Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang lvd, Wuhan 430030, Hubei, P.R. China.
推荐引用方式(GB/T 7714)：
Yi Huang,Jinli Wang,Mandi Luo,et al.Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway.[J].Aging medicine (Milton (N.S.W)).2020,3(3):153-158.doi:10.1002/agm2.12125.
APA：
Yi Huang,Jinli Wang,Mandi Luo,Dan Yan&Cuntai Zhang.(2020).Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway..Aging medicine (Milton (N.S.W)),3,(3)
MLA：
Yi Huang,et al."Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway.".Aging medicine (Milton (N.S.W)) 3..3(2020):153-158

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