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The animal model in ABO-incompatible organ transplantation (Book Chapter)

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作者：

单位： [1]Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [2]Key Laboratory of Organ Transplantation, Ministry of Education/Ministry of Public Health, Wuhan, China [3]Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China

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关键词： Animal model Humoral rejection models Nonhuman primates

摘要：

To better understand the mechanisms of such antibody-mediated rejection and explore novel strategies for clinical application, it is important to establish an animal research model of humoral rejection in ABO-incompatible organ transplantation. In this chapter, we will discuss the following issues: the ABO tissue groups and blood groups in nonhuman primates, natural anti-blood group antibody levels in sera of nonhuman primates, outcomes of ABO-incompatible organ transplantation in nonhuman primates, and establishment of humoral rejection models in ABO-incompatible organ transplantation in nonhuman primates. © Springer Nature Singapore Pte Ltd. 2019. All rights reserved.

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第一作者：

第一作者单位： [1]Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [2]Key Laboratory of Organ Transplantation, Ministry of Education/Ministry of Public Health, Wuhan, China [3]Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China

通讯作者：

通讯机构： [1]Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China [2]Key Laboratory of Organ Transplantation, Ministry of Education/Ministry of Public Health, Wuhan, China

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