单位：[1]Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China华中科技大学同济医学院附属同济医院眼科[2]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China华中科技大学同济医学院附属同济医院检验科[3]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China华中科技大学同济医学院附属同济医院放射科[4]Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Purpose To investigate the association between serum immunoglobulin G4 (IgG4) levels and laboratorial parameters. Moreover, the ocular manifestations were compared in Graves' ophthalmopathy (GO) patients. Methods Fifty-seven GO patients and fifty sex- and age-matched euthyroid subjects were enrolled. Serum IgG4 and immunoglobulin G (IgG) levels, thyroid hormones and thyroid autoantibodies were measured in all participants. Ophthalmologic examinations were performed to GO patients. Results Serum IgG4 levels were increased in GO patients compared with euthyroid subjects (p<0.001). Multivariate analysis showed that TRAb levels were correlated with IgG4 levels in GO patients (beta=1.45, p = 0.024). There were eight GO patients with IgG4 levels >= 135 mg/dL. They all had both eyelids swelling and the differences of HER were less than 2mm. Seven patients (7/8) showed bilateral symmetrical thickening of the extraocular muscles. Conclusions Bilateral symmetry of ocular manifestation was observed in GO patients with IgG4 levels >= 135 mg/dL. IgG4 levels may be helpful in monitoring GO and diagnosing a new subtype of GO.
基金：
Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2019CFB494]
第一作者单位：[1]Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
通讯作者：
通讯机构：[1]Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China[*1]Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
推荐引用方式(GB/T 7714)：
Luo Ban,Yuan Xu,Wang Wei,et al.Ocular Manifestations and Clinical Implications of Serum Immunoglobulin G4 Levels in Graves' Ophthalmopathy Patients[J].OCULAR IMMUNOLOGY AND INFLAMMATION.2022,30(3):580-587.doi:10.1080/09273948.2020.1826537.
APA：
Luo, Ban,Yuan, Xu,Wang, Wei,Zhang, Jing,Liu, Rong...&Chen, Liwen.(2022).Ocular Manifestations and Clinical Implications of Serum Immunoglobulin G4 Levels in Graves' Ophthalmopathy Patients.OCULAR IMMUNOLOGY AND INFLAMMATION,30,(3)
MLA：
Luo, Ban,et al."Ocular Manifestations and Clinical Implications of Serum Immunoglobulin G4 Levels in Graves' Ophthalmopathy Patients".OCULAR IMMUNOLOGY AND INFLAMMATION 30..3(2022):580-587
