Background: Machine learning (ML) may be helpful to simplify the risk stratification of coronary artery disease (CAD). The current study aims to establish a ML-aided risk stratification system to simplify the procedure of the diagnosis of CAD. Methods and results: 5819 patients with coronary artery angiography (CAG) from July 2015 and December 2018 in our hospital, 2583 patients (aged 56 +/- 11, <50% stenosis) and 3236 patients (aged 60 +/- 10, >= 50% stenosis), available on age, sex, history of smoking, systolic and diastolic blood pressure, total cholesterol level, low- and high-density lipoprotein, triglyceride level, glycosylated hemoglobin Mc and uric add were included in the ensemble model of ML Receiver-operating characteristic curves showed that area-under-the-curve of the training data (90%) and the testing data (10%) were 0.81 and 0.75 (P = 0.006483). The validation data of 582 patients with CAG from July 2019 to September 2019 in our hospital showed the same predictive rate of the testing data. The low-risk group (risk probability<0.2) without the treatment of hypertension, diabetes and CAD could be probably excluded the diagnosis of CAD, the moderate-risk group (risk probability 0.2-0.8) would need further examination, and high-risk group (risk probability>0.8) would suggested to perform CAG directly. Conclusion: Machine learning-aided detection system with the clinical data of age, sex, history of smoking, systolic and diastolic blood pressure, total cholesterol level, low- and high-density lipoprotein, triglyceride level, glycosylated hemoglobin A1c and uric acid could be helpful for the risk stratification of prediction for the coronary artery disease. (C) 2020 Published by Elsevier B.V.