International guidelines recommendBRCAtesting for patients with breast and ovarian cancer. Little is known about the genetic testing practices ofBRCA1/2mutations in laboratories across China. This study was designed to assess the discrepancies in genetic testing procedures ofBRCA1/2mutations across China. An online survey was developed for depicting theBRCA1/2testing landscape in China. Our results show that there were several variations among the laboratories in technologies adopted, large genomic rearrangement detection, probe design, quality control, variant of uncertain significance interpretation, and disposition of variants in public databases. The discrepancies observed in our study would affect the authenticity of results, thus necessitating the formulation of proper national and international guidelines for optimalBRCA1/2testing clinical practice for efficient management and patient care of this population.