C-terminal binding protein-2 (CtBP2) a transcriptional corepressor, has been reported to involve in tumorigenesis and progression and predict a poor prognosis in several human cancers. However, few studies on CtBP2 in lung cancer tissues have been performed. In the present study, we first explored theCtBP2gene expression profile from the the cancer genome atlas (TCGA) datasets, then western blot analysis and immunohistochemistry were performed to investigate and verified whether lung adenocarcinoma (LUAD) tissues exhibit deregulated CtBP2 expression. We evaluated the correlations between CtBP2 expression and the clinicopathological characteristics, and Kaplan-Meier survival analyses were performed to estimate the effect of CtBP2 expression on prognosis of LUAD patients. The results revealed that CtBP2 expression was significantly upregulated in LUAD tissues compared with normal lung tissues. Furthermore, increasing CtBP2 expression in LUAD was significantly associated with tumor differentiation (P = .028), tumor node metastasis (TNM) stage (P = .042). CtBP2 expression was significantly correlated with LUAD patients' survival (P = .028). In conclusion, the present study revealed that CtBP2 protein is a novel prognostic marker for LUAD. A further large-scale study is needed to confirm the present results.
第一作者单位：[1]Hubei Canc Hosp, Dept Thorac Surg, 116 Zhudao Spring South Rd, Wuhan, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Binfeng,Xiang Zhengkai,Xiong Fei,et al.C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas[J].MEDICINE.2020,99(31):doi:10.1097/MD.0000000000020076.
APA：
Li, Binfeng,Xiang, Zhengkai,Xiong, Fei,Yan, Baoguo&Huang, Qi.(2020).C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas.MEDICINE,99,(31)
MLA：
Li, Binfeng,et al."C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas".MEDICINE 99..31(2020)
