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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Yasuo Oguri[1,2,3,4] * ; Kosaku Shinoda[1,2,3,5] * ; Hyeonwoo Kim[6] * ; Diana L. Alba[1,7] ; W. Reid Bolus[1,7] ; Qiang Wang[1,2,3,4] ; Zachary Brown[1,2,3] ; Rachana N. Pradhan[1,2,3] ; Kazuki Tajima[1,2,3] ; Takeshi Yoneshiro[1,2,3] ; Kenji Ikeda[1,2,3,8] ; Yong Chen[1,2,3,9] ; Rachel T. Cheang[1,7] ; Kazuyuki Tsujino[10] ; Caroline R. Kim[6] ; Vanille Juliette Greiner[1,11] ; Ritwik Datta[12] ; Christopher D. Yang[12] ; Kamran Atabai[12] ; Michael T. McManus[1,11] ; Suneil K. Koliwad[1,7] ; Bruce M. Spiegelman[6] ; Shingo Kajimura[1,2,3,4] ;
单位： [1]UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA [2]Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA [3]Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA [4]Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes & Metabolism, Harvard Medical School, Boston, MA, USA [5]Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA [6]Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA [7]Department of Medicine, University of California, San Francisco, San Francisco, CA, USA [8]Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan [9]Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [10]Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Osaka, Japan [11]Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA [12]Department of Medicine, Lung Biology Center, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
出处：
DOI： 10.1016/j.cell.2020.06.021
ISSN：

摘要：
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRα, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. CD81 forms a complex with αV/β1 and αV/β5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation. These results suggest that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis. Copyright © 2020 Elsevier Inc. All rights reserved.

基金编号： DK97441 DK112268 DK110098 DK110426 P30DK026687 5T32HL007374-38 UL1 TR000004 1-18-PMF-003 2019-D-004-FEL

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外文
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出版当年[2019]版：
大类 | 1 区 生物
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2018]版：
Q1 CELL BIOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者单位： [1]UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA [2]Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA [3]Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA [4]Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes & Metabolism, Harvard Medical School, Boston, MA, USA
共同第一作者：
通讯作者：
通讯机构： [1]UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA [2]Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA [3]Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA [4]Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes & Metabolism, Harvard Medical School, Boston, MA, USA
推荐引用方式(GB/T 7714)：
Yasuo Oguri,Kosaku Shinoda,Hyeonwoo Kim,et al.CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.[J].CELL.2020,182(3):563-+.doi:10.1016/j.cell.2020.06.021.
APA：
Yasuo Oguri,Kosaku Shinoda,Hyeonwoo Kim,Diana L. Alba,W. Reid Bolus...&Shingo Kajimura.(2020).CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling..CELL,182,(3)
MLA：
Yasuo Oguri,et al."CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.".CELL 182..3(2020):563-+

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