Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibrosis remain not investigated. In the present study, we used a PP2A inhibitor, a newly designed peptide named TAT-Y127WT, to determine the role of PP2A in pulmonary fibrosis. Herein, we showed that TAT-Y127WT protected mice against BLM-induced pulmonary fibrosis by attenuating lung injury and fibrosis. Furthermore, a mechanistic study indicated that TAT-Y127WT could alleviate EndMT in the lungs following BLM induction. Overall, our data showed that PP2A might participate in pulmonary fibrogenesis by promoting EndMT, and TAT-Y127WT could be a potential candidate for new anti-fibrotic therapies for IPF patients.
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Thorac Surg, Tongji Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China
通讯作者：
通讯机构：[2]Huazhong Univ Sci & Technol, Dept Nephrol, Tongji Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China[*1]Tongji Hosp, Dept Nephrol, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Yu Jun,Deng Yuanjun,Han Min.Blocking protein phosphatase 2A with a peptide protects mice against bleomycin-induced pulmonary fibrosis[J].EXPERIMENTAL LUNG RESEARCH.2020,46(7):234-242.doi:10.1080/01902148.2020.1774823.
APA：
Yu, Jun,Deng, Yuanjun&Han, Min.(2020).Blocking protein phosphatase 2A with a peptide protects mice against bleomycin-induced pulmonary fibrosis.EXPERIMENTAL LUNG RESEARCH,46,(7)
MLA：
Yu, Jun,et al."Blocking protein phosphatase 2A with a peptide protects mice against bleomycin-induced pulmonary fibrosis".EXPERIMENTAL LUNG RESEARCH 46..7(2020):234-242
