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Real-world use of the second-generation cobalt-chromium sirolimus-eluting stents: 12-month results from the prospective multicentre FOCUS registry

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单位： [a]Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China [b]Fuwai Cardiovascular Hospital, China [c]Beijing Anzhen Hospital, China [d]Xi'an Xijing Hospital, China [e]Tianjin Chest Hospital, China [f]Shanghai Tenth People's Hospital, China [g]People's Hospital of Liaoning Province, China [h]Putuo District Central Hospital of Shanghai, China [i]Shanghai Chest Hospital, China [j]Dalian Medical University, China [k]Guangdong General Hospital, China [l]People's Liberation Army General Hospital, China [m]Medical College of Qingdao University, China [n]Chengdu Militar General Hospital, China [o]Meizhou People's Hospital, China [p]Medical College of Xi'an Jiaotong University, China [q]First People's Hospital of Jining City, China [r]Jiangxi Provincial People's Hospital, China [s]General Hospital of Fushun Mining Group, China [t]Shanxi Provincial Institute of Cardiovascular Disease, China [u]Second Hospital of Jilin University, China [v]Cangzhou Central Hospital, China [w]Xiangya Hospital of Zhongnan University, China [x]Shanghai Changhai Hospital, China [y]Xingtai Cardiovascular Disease Hospital, China [z]Sir Run Run Shaw Hospital of Zhejiang University, China [aa]People's Hospital of Shanxi Province, China [ab]Second Clinical College of Harbin Medical University, China [ac]Armed Police Medical College Hospital, China [ad]Beijing Chaoyang Hospital, China [ae]People's Hospital of Peking University, China [af]Beijing Shijitan Hospital, China [ag]Daqing Oil Field General Hospital, China [ah]Shengjing Hospital of China Medical University, China [ai]Nanjing Drum Tower Hospital, China [aj]Huashan Hospital of Fudan University, China [ak]Shanghai Sixth People's Hospital, China [al]Shanghai Xinhua Hospital, China [am]Zhejiang University, China [an]Hangzhou First People's Hospital, China [ao]Nanjing First Hospital, China [ap]Xuzhou Centre Hospital, China [aq]Guangdong Medical College, China [ar]Weifang Yidu Zhongxin Hospital, China [as]Lanzhou University, China [at]Kunming Medical College, China [au]Wuhan Tongji Hospital of Huazhong University of Science and Technology, China [av]Wuhan University Renmin Hospital, China [aw]Xiangfan City Central Hospital, China [ax]Wuhan Asia Heart Hospital, China [ay]First People's Hospital of Yulin City, China [az]Beijing Luhe Hospital, China [ba]Sun Yat-sen University, China [bb]Zhujiang Hospital, China [bc]First Clinical College of Harbin Medical University, China [bd]People's Hospital of Guangxi Zhuang Autonomous Region, China [be]Shanghai Renji Hospital, China [bf]Third Hospital of Peking University, China [bg]China Medical University, China [bh]Jiangsu University, China [bi]Yantai Yuhuangding Hospital, China [bj]Qilu Hospital of Shandong University, China [bk]Xiangtan Central Hospital, China [bl]Shanghai Huadong Hospital, China [bm]Shandong Provincial Hospital, China [bn]Fujian Medical University Union Hospital, China [bo]Tongji Hospital of Tongji University, China [bp]Tianjin First Central Hospital, China [bq]Fourth Clinical College of Harbin Medical University, China [br]Zhongshan Hospital of Xiamen University, China [bs]First People's Hospital of Ningbo City, China [bt]Weifang Medical College, China [bu]Guangzhou Nanfang Hospital, Southern Medical University, China [bv]Wuhan Union Hospital, China [bw]Dalian 210 Hospital, China [bx]Chongqing Medical University, China [by]Shanghai Minhang District Central Hospital, China [bz]Siriraj Hospital of Mahidol University, Bangkok, Thailand [ca]Bina Waluya Cardiac Hospital, Indonesia [cb]Medistra Hospital, Indonesia

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关键词： Cobalt-chromium stent Coronary artery disease Sirolimus-eluting stent

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Aims: The FOCUS registry is a prospective, multicentre, web-based programme designed to collect clinical outcome data from real-world patients receiving the second-generation cobalt-chromium sirolimus-eluting stent (CoCr-SES). Methods and results: From March 2009 to February 2010, a total of 5,084 patients from 83 centres who were eligible to receive CoCr-SES were enrolled in the FOCUS registry. The primary endpoint was 12-month major adverse cardiac events (MACE, defined as the composite of cardiac death, myocardial infarction [MI], and target vessel revascularisation [TVR]). One-year data were available for 5,013 (98.6%) of the 5,084 patients enrolled. The primary endpoint occurred in 174 (3.47%) of 5,013 patients, consisting of 43 (0.86%) cardiac deaths, 132 (2.63%) MI, and 46 (0.92%) TVR. According to the Academic Research Consortium definition, definite and probable stent thrombosis (ST) occurred in 0.52% (26/5,013) of patients, including 19 cases of early ST and 7 of late ST. The 12-month MACE rates were 3.73% and 2.60% for extended-use and standard-use patients, respectively (p=0.065). Conclusions: The second-generation CoCr-SES was associated with low rates of 12-month MACE and ST in a broad spectrum of patients, thereby confirming the clinical safety and efficacy of this stent in a real-world setting. © Europa Digital & Publishing 2012. All rights reserved.

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第一作者单位： [a]Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

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Real-world use of the second-generation cobalt-chromium sirolimus-eluting stents: 12-month results from the prospective multicentre FOCUS registry

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