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Research on the expression of HOXA10 in placental villi during the onset of labor

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单位： [a]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical School,Huazhong University of Science and Technology,Wuhan 430030,China [b]Department of Obstetrics and Gynecology, Xiamen First Hospital, Fujian Medical University, Xiamen 350005, China

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关键词： HOXA10 Labor onset Placental villi Progesterone

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Objective: To investigate the difference of the expression of HOXA10 gene in placental villi before and after the onset of labor. Methods: Immunohistochemistry was used to detect the location of HOXA10 in placental villi. The expression of HOXA10 mRNA and protein were measured by RT-PCR and Western blotting. Results: Immunohistochemistry showed that HOXA10 was only weakly expressed in placental villi of the natural labor group. However, it was strongly expressed in placental villi of the surgical labor group. RT-PCR and Western blotting showed that the expression of HOXA10 mRNA and protein were significantly lower in the natural labor group than in the surgical labor group (P<0.05). Conclusions: The lower expression of HOXA10 during the onset of labor may be one of the major factors in initiating the normal labor. And to some extent, the lower expression of HOXA10 gene in the natural labor group may be related to "functional progesterone withdrawal". © 2012 The Editorial Board of Journal of Reproduction and Contraception.

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第一作者单位： [a]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical School,Huazhong University of Science and Technology,Wuhan 430030,China

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