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Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer

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作者：
Yu, Z[a,b,c] * ; Wang, L[a,b] ; Wang, C[a,b] ; Ju, X[a,b] ; Wang, M[a,b] ; Chen, K[a,b] ; Loro, E[a,b] ; Li, Z[a,b] ; Zhang, Y[c] ; Wu, K[a,b,f] ; Casimiro, M.C[a,b] ; Gormley, M[a,b] ; Ertel, A[a,b] ; Fortina, P[a,b] ; Chen, Y[c] ; Tozeren, A[b,d,e] ; Liu, Z[c] ; Pestell, R.G[a,b] ;
单位： [a]Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pa 19107, United States [b]Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, United States [c]Research Center for Translational Medicine, Key Laboratory for Basic Research in Cardiology, Tongji University School of Medicine, 150 Jimo Road, Shanghai 200120, China [d]Center for Integrated Bioinformatics, Drexel University, Philadelphia, PA 19104, United States [e]School of Biomedical Engineering, Systems and Health Sciences, Drexel University, Philadelphia, PA 19104, United States [f]Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1038/ncomms3812
ISSN：

摘要：
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates the pRB protein and promotes G 1 /S cell-cycle progression and oncogenesis. Dicer is a central regulator of miRNA maturation, encoding an enzyme that cleaves double-stranded RNA or stem-loop-stem RNA into 20-25 nucleotide long small RNA, governing sequence-specific gene silencing and heterochromatin methylation. The mechanism by which the cell cycle directly controls the non-coding genome is poorly understood. Here we show that cyclin D1 -/- cells are defective in pre-miRNA processing which is restored by cyclin D1a rescue. Cyclin D1 induces Dicer expression in vitro and in vivo. Dicer is transcriptionally targeted by cyclin D1, via a cdk-independent mechanism. Cyclin D1 and Dicer expression significantly correlates in luminal A and basal-like subtypes of human breast cancer. Cyclin D1 and Dicer maintain heterochromatic histone modification (Tri-m-H3K9). Cyclin D1-mediated cellular proliferation and migration is Dicer-dependent. We conclude that cyclin D1 induction of Dicer coordinates microRNA biogenesis. © 2013 Macmillan Publishers Limited. All rights reserved.

基金：
This work was supported in part by NIH grants (R01CA070896, R01CA075503, R01CA132115, R01CA107382 and R01CA086072 to R.G.P.), grants 2012CB966800 from National Basic Research Program of China and 81172515 from NSFC (to Yu. Z), the Kimmel Cancer Center NIH Cancer Center Core grant P30CA056036 (R.G.P.), generous grants from the Dr. Ralph and Marian C. Falk Medical Research Trust (R.G.P.) and a grant from the Pennsylvania Department of Health (R.G.P.). We thank Dr. Bert Vogelstein and Dr. Renato Baserga for providing the Dicer−/− HCT116 cells. We thank Dr. Gabriele DiSante for preparing 3XFlag cyclin D1 WT and N1 mutation vectors. We thank Dr. Richard Davidson for helpful discussions and editorial comments. The Department specifically disclaims responsibility for an analysis, interpretations or conclusions. There are no conflicts of interest associated with this manuscript.
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外文
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出版当年[2012]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
第一作者：
第一作者单位： [a]Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pa 19107, United States [b]Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, United States [c]Research Center for Translational Medicine, Key Laboratory for Basic Research in Cardiology, Tongji University School of Medicine, 150 Jimo Road, Shanghai 200120, China
通讯作者：
通讯机构： [a]Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pa 19107, United States [b]Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, United States
推荐引用方式(GB/T 7714)：
Yu Z,Wang L,Wang C,et al.Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer[J].Nature Communications.2013,4:doi:10.1038/ncomms3812.
APA：
Yu, Z,Wang, L,Wang, C,Ju, X,Wang, M...&Pestell, R.G.(2013).Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer.Nature Communications,4,
MLA：
Yu, Z,et al."Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer".Nature Communications 4.(2013)

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