单位：[1]Department of Hepatology, Taizhou People’s Hospital, Jiangsu, China[2]Department of Pathology, Taizhou People’s Hospital, Jiangsu, China[3]National Engineering Center for Biochip at Shanghai, Shanghai, China[4]CMC Biobank and Translational medicine Institute, Jiangsu, China[5]Department of Oncology, Taizhou People’s Hospital, Jiangsu, China[6]Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital affiliated to Tongji Medical College, Tongji University, Shanghai, China[7]Shanghai Engineering Center for Molecular Medicine, Shanghai, China
Autophagy is a fundamental cell biological process that confers stress tolerance, limits damage, and sustains viability under adverse conditions. Defective autophagy is associated with diverse diseases. The study aimed to investigate the relationship between UNC51-like kinase 1 (ULK1) expression and clinicopathological characteristics as well as survival in patients with hepatocellular carcinoma (HCC). Expression levels of ULK1 in 55 paired HCC and paracancerous tissues were examined using immunohistochemistry. Although not statistically significant, the expression of ULK1 in adjacent peritumoural tissue was lower than those in HCC tissues (P = 0.113). Expression level of ULK1 was significantly associated with tumor size (P = 0.015) after adjusted for age, sex, histologic grade, cirrhosis and TNM. Survival analysis showed that patients with high ULK1 expression had worse survival time than those with low ULK1 expression (hazard rate = 2.684, 95% CI 1.029-7.006, P = 0.044). The findings of the present study provide evidence that ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC.
基金：
This work was supported by the 12th Five-Year Plan Key Project of Science and Technology, China (No. 2013ZX10002007).
语种：
外文
中科院(CAS)分区：
出版当年[2012]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2025]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
第一作者：
第一作者单位：[1]Department of Hepatology, Taizhou People’s Hospital, Jiangsu, China
通讯作者：
通讯机构：[5]Department of Oncology, Taizhou People’s Hospital, Jiangsu, China[6]Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital affiliated to Tongji Medical College, Tongji University, Shanghai, China[7]Shanghai Engineering Center for Molecular Medicine, Shanghai, China[*1]Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital affiliated to Tongji Medical College, Tongji University, Shanghai, China.[*2]Department of Oncology, Taizhou People’s Hospital, Jiangsu, China.
推荐引用方式(GB/T 7714)：
Xu Hongtao,Yu Hong,Zhang Xiaoyan,et al.UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2013,6(4):711-717.
APA：
Xu, Hongtao,Yu, Hong,Zhang, Xiaoyan,Shen, Xiaoying,Zhang, Kehao...&Gao, Hengjun.(2013).UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,6,(4)
MLA：
Xu, Hongtao,et al."UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 6..4(2013):711-717
