Lethal triad of death is the most serious complication of multiple injuries, which often manifests as metabolic acidosis, hypothermia and coagulation disorder, and all lead to multiple organ dysfunction syndrome (MODS). During the treatment process, early effective control of all kinds of primary injuries and bleeding could maintain the stability of the internal environment for avoiding exhausting of patients’ physiological potential, then making it possible for patients to get definitive surgeries after resuscitation, which depends on the damage control theory (DCT). © 2017 Springer Nature Singapore Pte Ltd.