单位：[a]Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215, United States[b]Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States[c]Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, United States[d]Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States[e]Division of Thoracic Surgery, Tongji Hospital Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院外科学系胸外科
T lymphocytes undergo extensive changes in their metabolic properties during their transition through various differentiation states, from naïve to effector to memory or regulatory roles. The cause and effect relationship between metabolism and differentiation is a field of intense investigation. Many recent studies demonstrate the dependency of T cell functional outcomes on metabolic pathways and the possibility of metabolic intervention to modify these functions. In this review, we describe the basic metabolic features of T cells and new findings on how these correlate with various differentiation fates and functions. We also highlight the latest information regarding the main factors that affect T cell metabolic reprogramming.
基金：
This work was supported by NIH grants CA183605, CA183605S1 and AI098129-01 (to VAB), and by the DoD grant PC140571 (to VAB and PS).
语种：
外文
第一作者：
第一作者单位：[a]Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215, United States[b]Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States[c]Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, United States
通讯作者：
通讯机构：[a]Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215, United States[b]Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States[c]Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215, United States
推荐引用方式(GB/T 7714)：
Patsoukis N,Bardhan K,Weaver J,et al.The role of metabolic reprogramming in T cell fate and function[J].Current Trends in Immunology.2016,17:
APA：
Patsoukis, N,Bardhan, K,Weaver, J,Herbel, C,Seth, P...&Boussiotis, V.A.(2016).The role of metabolic reprogramming in T cell fate and function.Current Trends in Immunology,17,
MLA：
Patsoukis, N,et al."The role of metabolic reprogramming in T cell fate and function".Current Trends in Immunology 17.(2016)
