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Automatic multilabel electrocardiogram diagnosis of heart rhythm or conduction abnormalities with deep learning: a cohort study

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单位: [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Cardiol,Dept Internal Med, Wuhan, Hubei, Peoples R China [2]Huazhong Univ Sci AndTechnol, Sch Artificial Intelligence & Automat, MOE Key Lab Intelligent Control & Image Proc, Wuhan, Hubei, Peoples R China [3]Shanghai Jiao Tong Univ, Antai Coll Econ & Management, Shanghai, Peoples R China
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Background Market-applicable concurrent electrocardiogram (ECG) diagnosis for multiple heart abnormalities that covers a wide range of arrhythmias, with better-than-human accuracy, has not yet been developed. We therefore aimed to engineer a deep learning approach for the automated multilabel diagnosis of heart rhythm or conduction abnormalities by real-time ECG analysis. Methods We used a dataset of ECGs (standard 10 s, 12-channel format) from adult patients (aged >= 18 years), with 21 distinct rhythm classes, including most types of heart rhythm or conduction abnormalities, for the diagnosis of arrhythmias at multilabel level. The ECGs were collected from three campuses of Tongji Hospital (Huazhong University of Science and Technology, Wuhan, China) and annotated by cardiologists. We used these datasets to develop a convolutional neural network approach to generate diagnoses of arrythmias. We collected a test dataset of ECGs from a new group of patients not included in the training dataset. The test dataset was annotated by consensus of a committee of board-certified, actively practicing cardiologists. To evaluate the performance of the model we assessed the F1 score and the area under the curve (AUC) of the receiver operating characteristic (ROC) curve, as well as quantifying sensitivity and specificity. To validate our results, findings for the test dataset were compared with diagnoses made by 53 ECG physicians working in cardiology departments who had a wide range of experience in ECG interpretation (range 0 to >12 years). An external public validation dataset of 962 ECGs from other hospitals was used to study generalisability of the diagnostic model. Findings Our training and validation dataset comprised 180 112 ECGs from 70 692 patients, collected between Jan 1, 2012, and Apr 30, 2019. The test dataset comprised 828 ECGs corresponding to 828 new patients, recorded between Sept 11, 2012, and Aug 30, 2019. At the multilabel level, our deep learning approach to diagnosing heart abnormalities resulted in an exact match in 658 (80%) of 828 ECGs, exceeding the mean performance of physicians (552 [67%] for physicians with 0-6 years of experience; 571 [69%] for physicians with 7-12 years of experience; 621 [75%] for physicians with more than 12 years of experience). Our model had an overall mean F1 score of 0 center dot 887 compared with 0 center dot 789 for physicians with 0-6 years of experience, 0 center dot 815 for physicians with 7-12 years of experience, and 0 center dot 831 for physicians with more than 12 years of experience. The model had a mean AUC ROC score of 0 center dot 983 (95% CI 0 center dot 980-0 center dot 986), sensitivity of 0 center dot 867 (0 center dot 849-0 center dot 885) and specificity of 0 center dot 995 (0 center dot 994-0 center dot 996). Promising F1 scores were also obtained from the external public database using our proposed model without any model modifications (mean F1 scores of 0 center dot 845 in multilabel and 0 center dot 852 in single-label ECGs). Interpretation Our model is more accurate than physicians working in cardiology departments at distinguishing a range of distinct arrhythmias in single-label and multilabel ECGs, laying a promising foundation for computational decision-support systems in clinical applications. Copyright (c) 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.

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大类 | 1 区 医学
小类 | 1 区 医学:信息 1 区 医学:内科
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Q1 MEDICAL INFORMATICS Q1 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版]

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第一作者单位: [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Cardiol,Dept Internal Med, Wuhan, Hubei, Peoples R China
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通讯机构: [2]Huazhong Univ Sci AndTechnol, Sch Artificial Intelligence & Automat, MOE Key Lab Intelligent Control & Image Proc, Wuhan, Hubei, Peoples R China [*1]Huazhong Univ Sci & Technol, Sch Artificial Intelligence & Automat, Wuhan 430074, Peoples R China
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