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CRISPR as a tool in tumor therapy: A short review

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收录情况： ◇ SCIE ◇ EI

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单位： [1]Huazhong Univ Sci & Technol, Dept Pediat, Tongji Med Coll, Tongji Hosp, Wuhan, Hubei, Peoples R China

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关键词： CRISPR gene therapy tumor

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Tumors remain a health concern worldwide, and gene therapy is a useful approach for treating tumors. The Clustered regulatory interspaced short palindromic repeat (CRISPR) system, an efficient and robust gene-editing system originating from bacteria, serves as an important tool in gene therapy. In this review, we briefly summarize the usage of CRISPR (including in gene knockout and gene knock-in applications) and the CRISPRa system in tumor therapy, including its delivery approaches and the general fields in which it has been applied. We summarize the application of the CRISPR system in tumor therapy in two aspects: its application in tumor cell modification and its application in drug engineering. This review also summarizes the advantages and challenges of using the CRISPR system in tumor therapy. (C) 2020 International Union of Biochemistry and Molecular Biology, Inc.

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出版当年[2019]版：

大类 | 4 区工程技术

小类 | 4 区生化与分子生物学 4 区生物工程与应用微生物

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物工程与应用微生物

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出版当年[2018]版：

Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

影响因子： 3.2 最新[2023版] 3 最新五年平均 1.559 出版当年[2018版] 1.498 出版当年五年平均 1.44 出版前一年[2017版] 1.638 出版后一年[2019版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Dept Pediat, Tongji Med Coll, Tongji Hosp, Wuhan, Hubei, Peoples R China

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