Here, we show that heat shock cognate protein 70 (Hsc70) in shrimp cells can inhibit apoptosis induced by white spot syndrome virus (WSSV) infection. Caspase-3 protease activity of hemocytes increased significantly, correlating with a reduction in endogenous Hsc70 late in WSSV infection. Hsc70 dsRNA caused a significant increase in caspase-3 activity in the hemocytes of non-infected shrimp and WSSV-infected shrimp. We propose that upregulation of Hsc70 expression early in WSSV infection may also be used to prevent premature apoptotic cell death, and the precipitous downregulation of Hsc70 late in WSSV infection may lead to the timed induction of apoptosis.
基金：
National Nature Science Foundation of China [30800852, 30972276]; National 863 Project of China [2006AA09Z445]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Urol,Wuhan 430030,Hubei,Peoples R China[2]Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yan Feng,Xia Ding,Hu Jia,et al.Heat shock cognate protein 70 gene is required for prevention of apoptosis induced by WSSV infection[J].ARCHIVES OF VIROLOGY.2010,155(7):1077-1083.doi:10.1007/s00705-010-0686-0.
APA：
Yan, Feng,Xia, Ding,Hu, Jia,Yuan, Huixing,Zou, Tingting...&Xu, Hua.(2010).Heat shock cognate protein 70 gene is required for prevention of apoptosis induced by WSSV infection.ARCHIVES OF VIROLOGY,155,(7)
MLA：
Yan, Feng,et al."Heat shock cognate protein 70 gene is required for prevention of apoptosis induced by WSSV infection".ARCHIVES OF VIROLOGY 155..7(2010):1077-1083
