The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was introduced to estimate glomerular filtration rate (GFR) in chronic kidney disease (CKD) patients based on serum creatinine. The CKD-EPI equation shows better accuracy compared with the current gold standard equation, the Modification of Diet in Renal Disease (MDRD) equation, but it has not been externally validated in Chinese patients. This study compared the CKD-EPI equation with the original MDRD equation and two Chinese MDRD-based equations for estimating GFR in 200 Chinese CKD patients. The Tc-99m-diethylenetriamine penta-acetate (Tc-99m-DTPA) method was used to determine actual GFR. The CKD-EPI equation produced GFR estimates that were more consistent with the Tc-99m-DTPA GFR than did the MDRD equations. The precision and accuracy of the CKD-EPI equation were significantly higher than those of the MDRD equations. In conclusion, the CKD-EPI equation was superior to the existing MDRD equations in terms of estimating GFR and we recommend its clinical use in Chinese CKD patients.
基金：
National Natural Science Foundation of China for Young Scholar [30800525]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2009]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Div Nephrol, Tongji Med Coll, Wuhan 430030, Hunan, Peoples R China[3]Zhongxiang Renmin Hosp, Dept Internal Med, Zhongxiang, Hubei, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Div Nephrol, Tongji Med Coll, Wuhan 430030, Hunan, Peoples R China[*1]Huazhong Univ Sci & Technol, Tongji Hosp, Div Nephrol, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Hunan, Peoples R China
推荐引用方式(GB/T 7714)：
Liao Y.,Liao W.,Liu J.,et al.Assessment of the CKD-EPI Equation to Estimate Glomerular Filtration Rate in Adults from a Chinese CKD Population[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2011,39(6):2273-2280.doi:10.1177/147323001103900624.
APA：
Liao, Y.,Liao, W.,Liu, J.,Xu, G.&Zeng, R..(2011).Assessment of the CKD-EPI Equation to Estimate Glomerular Filtration Rate in Adults from a Chinese CKD Population.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,39,(6)
MLA：
Liao, Y.,et al."Assessment of the CKD-EPI Equation to Estimate Glomerular Filtration Rate in Adults from a Chinese CKD Population".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 39..6(2011):2273-2280
