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Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women

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单位: [1]Zhejiang Tradit Chinese Med Hosp, Hangzhou 310006, Zhejiang, Peoples R China; [2]Zhejiang Chinese Med Univ, Affiliated Hosp 2, Hangzhou 310005, Zhejiang, Peoples R China; [3]Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; [4]Fudan Univ, Huashan Hosp, Shanghai 200040, Peoples R China; [5]Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China; [6]Shanghai Tongji Univ, Tongji Hosp, Shanghai 200065, Peoples R China; [7]Nanjing Brain Hosp, Nanjing 210029, Jiangsu, Peoples R China; [8]Jiangsu Univ, Affiliated Hosp 4, Zhenjiang 212001, Jiangsu, Peoples R China; [9]Tianjin Anding Hosp, Tianjin 300222, Peoples R China; [10]Shandong Mental Hlth Ctr, Jinan 250014, Shandong, Peoples R China; [11]Xi An Jiao Tong Univ, Coll Med, Hosp 1, Xian 710061, Shaanxi, Peoples R China; [12]Zhengzhou Univ, Hosp 1, Zhengzhou 450052, Henan, Peoples R China; [13]Harbin Med Coll, Mental Hlth Ctr 1, Harbin, Heilongjiang, Peoples R China; [14]Sichuan Univ, Mental Hlth Ctr, W China Hosp, Chengdu 610041, Sichuan, Peoples R China; [15]Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China; [16]Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China; [17]China Med Univ, Shengjing Hosp, Shenyang 110817, Liaoning, Peoples R China; [18]Shenzhen Kangning Hosp, Shenzhen 518020, Peoples R China; [19]Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China; [20]Shanxi Med Univ, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China; [21]Mental Hosp Jiangxi Prov, Nanchang 330029, Jiangxi, Peoples R China; [22]Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China; [23]Wuhan Mental Hlth Ctr, Wuhan 430022, Peoples R China; [24]3 Hosp Heilongjiang Prov, Beian, Heilongjiang, Peoples R China; [25]Jilin Brain Hosp, Siping 136000, Jilin, Peoples R China; [26]China Med Univ, Hosp 1, Shenyang 110001, Peoples R China; [27]Dalian 7 Peoples Hosp, Dalian, Peoples R China; [28]Dalian Mental Hlth Ctr, Dalian, Peoples R China; [29]Hebei Med Univ, Hosp 1, Shijiazhuang 050031, Peoples R China; [30]Lanzhou Univ, Lanzhou Univ Hosp 2, Clin Med Coll 2, Lanzhou 730030, Gansu, Peoples R China; [31]Psychiat Hosp Henan Prov, Xinxiang, Henan, Peoples R China; [32]Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China; [33]4 Peoples Hosp Liaocheng, Liaocheng 252000, Shandong, Peoples R China; [34]Guangzhou Psychiat Hosp, Guangzhou Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China; [35]Clin Trial Serv Unit, Oxford OX3 7LF, England; [36]Virginia Commonwealth Univ, Dept Psychiat, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA; [37]Zhejiang Tradit Chinese Med Hosp, 54 You Dian Rd, Hangzhou 310006, Zhejiang, Peoples R China
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关键词: Major depressive disorder Stressful life event Social adversity Symptom

摘要:
Background: In European and US studies, patients with major depressive disorder (MDD) report more stressful life events (SLEs) than controls, but this relationship has rarely been studied in Chinese populations. Methods: Sixteen lifetime SLEs were assessed at interview in two groups of Han Chinese women: 1970 clinically ascertained with recurrent MDD and 2597 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression. Results: 60% of controls and 72% of cases reported at least one lifetime SLE. Fourteen of the sixteen SLEs occurred significantly more frequently in those with MDD (median odds ratio of 1.6). The three SLEs most strongly associated with risk for MDD (OR>3.0) preceded the onset of MDD the majority of the time: rape (82%), physical abuse (100%) and serious neglect (99%). Limitations: Our results may apply to females only. SLEs were rated retrospectively and are subject to biases in recollection. We did not assess contextual information for each life event. Conclusions: More severe SLEs are more strongly associated with MDD. These results support the involvement of psychosocial adversity in the etiology of MDD in China. (C) 2011 Elsevier B.V. All rights reserved.

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出版当年[2010]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 3 区 精神病学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 精神病学
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出版当年[2009]版:
Q1 PSYCHIATRY Q1 CLINICAL NEUROLOGY
最新[2023]版:
Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY

影响因子: 最新[2023版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

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第一作者单位: [2]Zhejiang Chinese Med Univ, Affiliated Hosp 2, Hangzhou 310005, Zhejiang, Peoples R China;
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