Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) had usually been reported to improve the symptoms of advanced Parkinson's disease. Previous studies showed that neurons in the PFTg involved in the control of the sympathetic outflow to the kidneys. Our recent studies using transneuronal labeling pseudorabies virus (PRV)-614 supported the sympathetic nature of the caudal PFTg. We propose a hypothesis that deep brain stimulation of the PPTg may influence renal function by serotonergic and catecholaminergic pathways. Because PRV-614/tryptophan hydroxylase and PRV-614/tyrosine hydroxylase double-labeled neurons in the compact parts of PPTg (cpPPTg) were not detected, deep brain stimulation of the cpPPTg might not influence renal function. (c) 2011 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of P.R.China [81071307]; Wuhan Public Health Bureau [WX08C09]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan Pu Ai Hosp, Dept Pain Management, Wuhan 430010, Hubei, Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Anesthesiol & Pain Med,Wuhan 430030,Hubei,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xiang Hong-Bing,Liu Cheng,Guo Qing-Qing,et al.Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function[J].MEDICAL HYPOTHESES.2011,77(6):1135-1138.doi:10.1016/j.mehy.2011.09.022.
APA：
Xiang, Hong-Bing,Liu, Cheng,Guo, Qing-Qing,Li, Rong-Chun&Ye, Da-Wei.(2011).Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function.MEDICAL HYPOTHESES,77,(6)
MLA：
Xiang, Hong-Bing,et al."Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function".MEDICAL HYPOTHESES 77..6(2011):1135-1138
