Objective: To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP). Methods: Thirty-three CRSnNP patients were enrolled and subjected to CAM treatment for 12 weeks (250 mg daily). The total nasal symptom scores (TNSS), nasal resistance and inflammatory mediators including interleukin (IL)-8 and myeloperoxidase (MPO) were evaluated at weeks 0 and 12. Quality of life (QoL) was assessed in all patients by using the Sinonasal Outcome Test 20 and Short Form 36 questionnaires. Results: CAM treatment significantly improved TNSS, nasal resistance and QoL, and it inhibited IL-8 and MPO production in CRSnNP patients (p < 0.05). CAM treatment was more effective for IL-8(high) CRSnNP patients than for IL-8(low) CRSnNP patients (p < 0.05). Conclusion: Long-term, low-dose CAM treatment is effective and safe for the treatment of CRSnNP in Chinese patients. Copyright (C) 2011 S. Karger AG, Basel
基金：
National Natural Science Grants of China [30872845, 81070771, 81070772, 81020108018]; Guangdong Province Natural Science Grant [2010B031600088]
第一作者单位：[1]Sun Yat Sen Univ, Affiliated Hosp 1, Otorhinolaryngol Hosp, Allergy & Canc Ctr, Guangzhou 510080, Guangdong, Peoples R China[2]Sun Yat Sen Univ, Otorhinolaryngol Inst, Guangzhou 510080, Guangdong, Peoples R China
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Affiliated Hosp 1, Otorhinolaryngol Hosp, Allergy & Canc Ctr, Guangzhou 510080, Guangdong, Peoples R China[2]Sun Yat Sen Univ, Otorhinolaryngol Inst, Guangzhou 510080, Guangdong, Peoples R China[*1]Sun Yat Sen Univ, Affiliated Hosp 1, Otorhinolaryngol Hosp, Allergy & Canc Ctr, 58 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Luo Qing,Chen Fenghong,Liu Wenlong,et al.Evaluation of Long-Term Clarithromycin Treatment in Adult Chinese Patients with Chronic Rhinosinusitis without Nasal Polyps[J].ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES.2011,73(4):206-211.doi:10.1159/000328342.
APA：
Luo, Qing,Chen, Fenghong,Liu, Wenlong,Li, Zuwang,Xu, Rui...&Li, Huabin.(2011).Evaluation of Long-Term Clarithromycin Treatment in Adult Chinese Patients with Chronic Rhinosinusitis without Nasal Polyps.ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES,73,(4)
MLA：
Luo, Qing,et al."Evaluation of Long-Term Clarithromycin Treatment in Adult Chinese Patients with Chronic Rhinosinusitis without Nasal Polyps".ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 73..4(2011):206-211
