Both markers were expressed abundantly and staining of nestin significantly increased with WHO grade. Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival. Our findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis.
基金:
Helmholtz Society [NT-GE-016+062]; Verein zur Forderung der Krebsforschung in Deutschland; Bundesministerium fur Bildung und Forschung [01GS0886]; Tumorzentrum Heidelberg-Mannheim
Wan Feng,Herold-Mende Christel,Campos Benito,et al.Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas[J].BIOMARKERS.2011,16(2):136-143.doi:10.3109/1354750X.2010.536256.
APA:
Wan, Feng,Herold-Mende, Christel,Campos, Benito,Centner, Franz-Simon,Dictus, Christine...&Ahmadi, Rezvan.(2011).Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas.BIOMARKERS,16,(2)
MLA:
Wan, Feng,et al."Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas".BIOMARKERS 16..2(2011):136-143