Arrhythmias is one of the leading causes of death in the world. Current antiarrhythmic drugs are limited by unsatisfactory efficacy and adverse effects such as proarrhythmias. Reentry mechanism plays an important role in persistence of arrhythmias. Reentry can only continue when reentry path-length is longer than cardiac wavelength which is equal to the product of conduction velocity (CV) and effective refractory period (ERP). Gap junctions uncoupling is associated with proarrhythmic CV slowing and transmural dispersion of repolarization (TDR) increasing in many cardiac diseases. Vaughan Williams class Ill antiarrhythmic drugs prolong ERP with an augmented TDR which is the main mechanism of the proarrhythmic effects. Gap junctions enhancer can augment CV and diminish TDR. As a result, gap junctions enhancer combined with class Ill drugs may be a promising antiarrhythmic method. (C) 2010 Elsevier Ltd. All rights reserved.
基金：
National Nature and Science Foundation of China [NSFC30770879]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Geriatr, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Lian-dong,Zhang Cun-tai,Ruan Lei,et al.Gap junctions enhancer combined with Vaughan Williams class III antiarrhythmic drugs, a promising antiarrhythmic method?[J].MEDICAL HYPOTHESES.2011,76(1):119-121.doi:10.1016/j.mehy.2010.08.047.
APA：
Li, Lian-dong,Zhang, Cun-tai,Ruan, Lei,Ni, Ming-ke&Quan, Xiao-qing.(2011).Gap junctions enhancer combined with Vaughan Williams class III antiarrhythmic drugs, a promising antiarrhythmic method?.MEDICAL HYPOTHESES,76,(1)
MLA：
Li, Lian-dong,et al."Gap junctions enhancer combined with Vaughan Williams class III antiarrhythmic drugs, a promising antiarrhythmic method?".MEDICAL HYPOTHESES 76..1(2011):119-121
