Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 nonsmall cell lung carcinomas (NSCLCs) with matched adjacent normal lung tissues extracted from Chinese patients. In addition to the lung cancerrelated genes (TP53, EGFR, KRAS, PIK3CA, and ROS1), this study revealed novel genes not previously implicated in NSCLC. Especially, matrix-remodeling associated 5 was the second most frequently mutated gene in NSCLC (first is TP53). Subsequent Sanger sequencing of matrix-remodeling associated 5 in an additional sample set consisting of 52 paired tumor-normal DNA samples revealed that 15% of Chinese NSCLCs contained somatic mutations in matrix-remodeling associated 5. These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC.
基金：
National Institutes of Health [7R01AT003203, 7R01AT005522, 5R01CA134433, 5R01CA134682, 5R01CA113793, 5R01CA129533]; Advancing a Healthier Wisconsin Fund
第一作者单位：[1]Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA[2]Med Coll Wisconsin, Ctr Canc, Milwaukee, WI 53226 USA
通讯作者：
通讯机构：[1]Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA[2]Med Coll Wisconsin, Ctr Canc, Milwaukee, WI 53226 USA
推荐引用方式(GB/T 7714)：
Xiong Donghai,Li Guangming,Li Kezhen,et al.Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients[J].CARCINOGENESIS.2012,33(9):1797-1805.doi:10.1093/carcin/bgs210.
APA：
Xiong, Donghai,Li, Guangming,Li, Kezhen,Xu, Qinzi,Pan, Zhongjie...&You, Ming.(2012).Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients.CARCINOGENESIS,33,(9)
MLA：
Xiong, Donghai,et al."Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients".CARCINOGENESIS 33..9(2012):1797-1805
