单位：[1]Huazhong Univ Sci & Technol,Dept Neurol,Tongji Hosp,Tongji Med Univ,Wuhan 430030,Hubei Province,Peoples R China神经内科华中科技大学同济医学院附属同济医院神经科[2]Minist Water Resources China, Beijing 100000, Peoples R China
In the present study, we transplanted bone marrow-derived mesenchymal stem cells into the CA3 area of the hippocampus of chronic epilepsy rats kindled by lithium chloride-pilocarpine. Immunofluorescence and western blotting revealed an increase in adenosine A1 receptor expression and a decrease in adenosine A2a receptor expression in the brain tissues of epileptic rats 3 months after transplantation. Moreover, the imbalance in the A1 adenosine receptor/A2a adenosine receptor ratio was improved. Electroencephalograms showed that frequency and amplitude of spikes in the hippocampus and frontal lobe were reduced. These results suggested that mesenchymal stem cell transplantation can reconstruct the normal function of the adenosine system in the brain and greatly improve epileptiform discharges.
第一作者单位：[1]Huazhong Univ Sci & Technol,Dept Neurol,Tongji Hosp,Tongji Med Univ,Wuhan 430030,Hubei Province,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Kang Huicong,Hu Qi,Liu Kiaoyan,et al.Reconstruction of the adenosine system by bone marrow-derived mesenchymal stem cell transplantation[J].NEURAL REGENERATION RESEARCH.2012,7(4):251-255.doi:10.3969/j.issn.1673-5374.2012.04.002.
APA：
Kang, Huicong,Hu, Qi,Liu, Kiaoyan,Liu, Yinhe,Xu, Feng...&Zhu, Suiqiang.(2012).Reconstruction of the adenosine system by bone marrow-derived mesenchymal stem cell transplantation.NEURAL REGENERATION RESEARCH,7,(4)
MLA：
Kang, Huicong,et al."Reconstruction of the adenosine system by bone marrow-derived mesenchymal stem cell transplantation".NEURAL REGENERATION RESEARCH 7..4(2012):251-255
