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Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis

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收录情况： ◇ SCIE

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单位： [1]Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Department of Urology, Wuhan No. 1 Hospital, Wuhan 430022, China

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关键词： TREM-1 Pseudomonos aeruginosa Macrophages Bacterial sepsis

摘要：

TREM-1 is a recently discovered receptor expressed on neutrophils and macrophages. Blocking of TREM-1 signaling improves the survival of mice with bacterial sepsis. However, the precise mechanism by which TREM-1 modulates the inflammatory responses is poorly defined. In this study, we investigated the role of TREM-1 in Pseudomonas aeruginosa-induced peritonitis. Our results showed that TREM-1 was not expressed on lymphocytes but emerged on the cell surface of neutrophils and peritoneal macrophages. Blockade of TREM-1 signaling significantly prolonged survival of mice with P. aeruginosa-induced peritonitis. However, blocking TREM-1 signaling had no effect on macrophage phagocytosis in vitro. Interestingly, the expression of the costimulatory molecules CD40 and CD86 on macrophages was significantly decreased after blocking TREM-1 signaling. Furthermore, interfering with TREM-1 engagement led to significant reduction of pro-inflammatory mediators such as IL-1, TNF-alpha, MCP-1 and IFN-gamma. Therefore, our results showed that TREM-1 could be a potential therapeutic target for bacterial sepsis. (C) 2011 Elsevier Inc. All rights reserved.

基金：

基金编号： 2009zx10004-107 2009zx10004-207

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出版当年[2011]版：

大类 | 3 区生物

小类 | 4 区细胞生物学 4 区免疫学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区细胞生物学 4 区免疫学

JCR分区：

出版当年[2010]版：

Q3 IMMUNOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 IMMUNOLOGY

影响因子： 3.7 最新[2023版] 4.1 最新五年平均 2.575 出版当年[2010版] 2.333 出版当年五年平均 2.698 出版前一年[2009版] 1.974 出版后一年[2011版]

第一作者：

第一作者单位： [1]Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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