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A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China

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收录情况： ◇ SCIE

作者：
Yang, Qiwen[1] * ; Zhang, Hui[1] ; Wang, Yao[1] ; Xu, Yingchun[1] ; Chen, Minjun[1] ; Badal, Robert E.[2] ; Wang, Hui[3] ; Ni, Yuxing[4] ; Yu, Yunsong[5] ; Hu, Bijie[6] ; Sun, Ziyong[7] ; Huang, Wenxiang[8] ; Wang, Yong[9] ; Wu, Anhua[10] ; Feng, Xianju[11] ; Liao, Kang[12] ; Shen, Dingxia[13] ; Hu, Zhidong[14] ; Chu, Yunzhuo[15] ; Lu, Juan[16] ; Cao, Bin[17] ; Su, Jianrong[18] ; Gui, Bingdong[19] ; Duan, Qiong[20] ; Zhang, Shufang[21] ; Shao, Haifeng[22] ; Kong, Haishen[23] ; Hu, Yunjian[24] ; Ye, Huifen[25] ;
单位： [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Clin Lab, Beijing 100730, Peoples R China [2]Int Hlth Management Associates Inc, Schaumburg, IL 60173 USA [3]Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China [4]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China [5]Zhejiang Univ, Sir RunRun Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China [6]Fu Dan Univ, Zhong Shan Hosp, Shanghai 200032, Peoples R China [7]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [8]Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China [9]Shandong Prov Hosp, Jinan 250021, Peoples R China [10]Cent Southern Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China [11]Zhengzhou Univ, Affiliated Hosp 1, Zhenzhou 450052, Peoples R China [12]Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China [13]Gen Hosp PLA, Beijing 100853, Peoples R China [14]Tianjin Med Univ, Gen Hosp, Tianjin 300052, Peoples R China [15]Chinese Med Univ, Affiliated Hosp 1, Shenyang 110001, Peoples R China [16]Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China [17]Capital Med Coll, Chaoyang Hosp, Beijing 100020, Peoples R China [18]Capital Med Coll, Friendship Hosp, Beijing 100020, Peoples R China [19]Second Affiliated Hospital of Nanchang University, Nanchang 330006, China [20]People’s Hospital of Jilin Province, Jilin 130021, China [21]People’s Hospital of Haikou City, Haikou 570208, China [22]General Hospital of Nanjing Military Command, Nanjing 210002, China [23]First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China [24]Beijing Hospital, Beijing 100730, China [25]Guangzhou First Municipal People’s Hospital, Guangzhou 510180, China
出处：
DOI： 10.1099/jmm.0.059816-0
ISSN：

摘要：
The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of 12 antibiotics against 3074 E. coli and 1025 K. pneumoniae from 23 centres located in 16 cities were determined by the broth microdilution method. During the 10 year study period, ertapenem, imipenem, amikacin and piperacillin-tazobactam retained high and stable activity against E. coli and K pneumoniae isolates regardless of whether their source was HA or CA and regardless of their extended-spectrum beta-lactamase (ESBL) production. However, the susceptibility of E coli to cephalosporins and ampicillin-sulbactam decreased dramatically during the 10 years, especially for the CA isolates. Fluoroquinolones showed low activity against E. coli. During the whole study period, the ESBL rates for E. coli isolates from IAIs increased from 36.1% in 2002-2003 to 68.1% in 2010-2011 (P<0.001). Correspondingly, the ESBL rates in HA isolates increased from 52.2% in 2002-2003 to 70.0% in 2010-2011 (P=0.001), and in CA isolates from 19.1% in 2002-2003 to 61.6% in 2010-2011 (P<0.001). The ESBL-positive rate in K. pneumoniae remained between 30.1 and 39.3% of the total isolates with no significant change during the 10 years. In conclusion, carbapenems retained the highest susceptibility rates against HA and CA E. coli and K. pneumoniae. High prevalence of ESBL in HA E. coli and fast-growing resistance in CA E. coli severely limit the empirical use of the third- and fourth-generation cephalosporins in the therapy of IAIs.

基金：
Merck Co., Inc.Merck & Company; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101287]; Research Special Fund for Public Welfare Industry of Health of China [201002021]

基金编号： 81101287 201002021

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类 | 3 区 医学
小类 | 4 区 微生物学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 微生物学
JCR分区：
出版当年[2011]版：
Q2 MICROBIOLOGY
最新[2023]版：
Q3 MICROBIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者单位： [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Clin Lab, Beijing 100730, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Qiwen,Zhang Hui,Wang Yao,et al.A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China[J].JOURNAL OF MEDICAL MICROBIOLOGY.2013,62:1343-1349.doi:10.1099/jmm.0.059816-0.
APA：
Yang, Qiwen,Zhang, Hui,Wang, Yao,Xu, Yingchun,Chen, Minjun...&Ye, Huifen.(2013).A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China.JOURNAL OF MEDICAL MICROBIOLOGY,62,
MLA：
Yang, Qiwen,et al."A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China".JOURNAL OF MEDICAL MICROBIOLOGY 62.(2013):1343-1349

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