Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) has been reported to improve gait disturbance in animal models of Parkinsonism and among patients with Parkinson's disease. Evidence suggests that neurons in the PPTg are involved in the control of the sympathetic outflow to the kidneys, and sympathetic regulation is a major component of central melanocortin action. Our recent studies using transneuronal labeling pseudorabies virus (PRV)-614 and melanocortin-4 receptor (MC4R)-green fluorescent protein (GFP) transgenic mice supported the melanocortinergic nature of the middle and caudal PPTg (mPPTg and cPPTg). Because PRV-614/MC4R-GFP double-labeled neurons in the mPPTg and cPPTg were detected, we propose a hypothesis that deep brain stimulation of the PPTg may influence renal function by the melanocortinergic pathway. (C) 2013 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of PR China [81071307, 81271766]; Innovation Project of Huazhong University of Science and Technology [2012TS060]; Clinical Key Disciplines Construction Grant from the Ministry of Health of PR China
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Anesthesiol & Pain Med, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Cheng,Ye Da-Wei,Guan Xue-Hai,et al.Stimulation of the pedunculopontine tegmental nucleus may affect renal function by melanocortinergic signaling[J].MEDICAL HYPOTHESES.2013,81(1):114-116.doi:10.1016/j.mehy.2013.03.045.
APA：
Liu, Cheng,Ye, Da-Wei,Guan, Xue-Hai,Li, Rong-Chun,Xiang, Hong-Bing&Zhu, Wen-Zhen.(2013).Stimulation of the pedunculopontine tegmental nucleus may affect renal function by melanocortinergic signaling.MEDICAL HYPOTHESES,81,(1)
MLA：
Liu, Cheng,et al."Stimulation of the pedunculopontine tegmental nucleus may affect renal function by melanocortinergic signaling".MEDICAL HYPOTHESES 81..1(2013):114-116
