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PAX5 alteration-associated gene-expression signatures in B-cell acute lymphoblastic leukemia

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hematol, Wuhan 430030, Peoples R China

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关键词： PAX5 B-cell acute lymphoblastic leukemia Bioinformatics

摘要：

The paired box domain gene 5 (PAX5) is frequently altered in both childhood and adult B-cell acute lymphoblastic leukemia, and takes part in leukemogenesis. We analyzed data from the database of Gene Expression Omnibus (accession number: GSE11877) using bioinformatical and statistical methods. The results showed that cases of PAX5 alteration can cluster using unsupervised clustering algorithms, and one gene, zinc and ring finger 1 (ZNRF1), was characterized and validated by quantitative RT-PCR. ZNRF1 may be associated with leukemogenesis of ALL with PAX5 alteration.

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出版当年[2012]版：

大类 | 4 区医学

小类 | 4 区血液学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区血液学

JCR分区：

出版当年[2011]版：

Q4 HEMATOLOGY

最新[2023]版：

Q3 HEMATOLOGY

影响因子： 1.7 最新[2023版] 1.8 最新五年平均 1.268 出版当年[2011版] 1.294 出版当年五年平均 1.324 出版前一年[2010版] 1.681 出版后一年[2012版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hematol, Wuhan 430030, Peoples R China

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通讯机构： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hematol, Wuhan 430030, Peoples R China [*1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hematol, 1095 Jiefang Da Dao, Wuhan 430030, Peoples R China

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