Angiogenesis plays a pivotal role in tumor growth. The hypoxia-inducible factor 1, alpha subunit (HIF-1 alpha)/vascular endothelial growth factor pathway is the most important pathway for regulating angiogenesis in the tumor microenvironment. c-Myc is an important oncogene that has many biological functions. In this study, we investigated the role of c-Myc in tumor angiogenesis. We found that the overexpression of c-Myc in colon cancer cells could promote the expression of HIF-1 alpha and that of vascular endothelial growth factor. Moreover, we found that c-Myc regulated HIF-1 alpha at the post-transcriptional level. The results revealed c-Myc-dependent regulation of HIF-1 alpha instead of HIF-1 alpha-dependent c-Myc regulation for the first time. They also showed that c-Myc was essential to regulate colon cancer cell-mediated angiogenesis and contributed to tumor growth. This research provides the theoretical basis for clinical trials of new therapeutic targets of c-Myc and HIF-1 alpha in colon cancer cells. (C) 2012 Elsevier Inc. All rights reserved.
基金：
foundation of "973" Program [2009CB521802]; National Natural Science foundation [30872472, 30973496, 81172512]
第一作者单位：[1]Huazhong Univ Sci & Technol,Canc Res Inst,Tongji Hosp,Wuhan 430030,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Cheng,Cai Shaoxin,Wang Guihua,et al.c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2013,430(2):505-511.doi:10.1016/j.bbrc.2012.12.006.
APA：
Chen, Cheng,Cai, Shaoxin,Wang, Guihua,Cao, Xiaonian,Yang, Xi...&Hu, Junbo.(2013).c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,430,(2)
MLA：
Chen, Cheng,et al."c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430..2(2013):505-511
