The aim of the present study was to evaluate whether ovarian stimulation could induce embryo implantation dysfunction in mice and to explore the possible mechanisms involved. Ovarian stimulation was performed with intraperitoneal injections of 0, 2.5, 5.0, 7.5 and 10.0 IU pregnant mare serum gonadotrophin followed by the same dose of human chorionic gonadotrophin 48 h later. A dose-dependent implantation defect in stimulated mice was demonstrated, which can be mainly explained by premature luteolysis and secondary endometrial changes induced by an imbalance in oestradiol and progesterone. RBMOnline (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of China [30801538]; Hubei Population and Family Planning Commission [JS2012003]; Central College Basic Scientific Research Business Special Fund [2012QN011]
第一作者单位：[1]Tongji Sch Pharm, Dept Chinese Herbs, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Deng Shaorong,Xu Jing,Zeng Jianwu,et al.Ovarian stimulation leads to a severe implantation defect in mice[J].REPRODUCTIVE BIOMEDICINE ONLINE.2013,27(2):172-175.doi:10.1016/j.rbmo.2013.03.018.
APA：
Deng, Shaorong,Xu, Jing,Zeng, Jianwu,Hu, Linli&Wu, Yunxia.(2013).Ovarian stimulation leads to a severe implantation defect in mice.REPRODUCTIVE BIOMEDICINE ONLINE,27,(2)
MLA：
Deng, Shaorong,et al."Ovarian stimulation leads to a severe implantation defect in mice".REPRODUCTIVE BIOMEDICINE ONLINE 27..2(2013):172-175
