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Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pediat, Wuhan 430022, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Orthoped, Wuhan 430022, Peoples R China

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关键词： Memory Scopolamine Tetramethylpyrazine Synapse

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Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia. (C) 2013 Elsevier B.V. All rights reserved.

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出版当年[2012]版：

大类 | 3 区医学

小类 | 3 区行为科学 3 区神经科学

最新[2025]版：

大类 | 3 区心理学

小类 | 3 区行为科学 4 区神经科学

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出版当年[2011]版：

Q1 BEHAVIORAL SCIENCES Q2 NEUROSCIENCES

最新[2023]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子： 2.6 最新[2023版] 2.8 最新五年平均 3.417 出版当年[2011版] 3.512 出版当年五年平均 3.393 出版前一年[2010版] 3.327 出版后一年[2012版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pediat, Wuhan 430022, Peoples R China

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