Kinsenoside (1) and goodyeroside A (2), two naturally occurring stereoisomers with diverse biological activities, have been synthesized efficiently by a chemo-enzymatic approach with a total yield of 12.7%. The aglycones, (R)- and (S)-3-hydroxy-gamma-butyrolactone, were prepared from D-and L-malic acid by a four-step chemical approach with a yield of 75%, respectively. These butyrolactones were then successfully glycosidated using beta-D-glucosidase as a catalyst in a homogeneous organic-water system. Under the optimized enzymatic conditions, the yields of kinsenoside and goodyeroside A in the enzymatic steps both reached 16.8%.
第一作者单位：[2]Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Yang,Xia Yihong,Lai Yongji,et al.Efficient Synthesis of Kinsenoside and Goodyeroside A by a Chemo-Enzymatic Approach[J].MOLECULES.2014,19(10):16950-16958.doi:10.3390/molecules191016950.
APA：
Zhang, Yang,Xia, Yihong,Lai, Yongji,Tang, Fang,Luo, Zengwei...&Zhang, Jinwen.(2014).Efficient Synthesis of Kinsenoside and Goodyeroside A by a Chemo-Enzymatic Approach.MOLECULES,19,(10)
MLA：
Zhang, Yang,et al."Efficient Synthesis of Kinsenoside and Goodyeroside A by a Chemo-Enzymatic Approach".MOLECULES 19..10(2014):16950-16958
