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Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China

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收录情况： ◇ SCIE

作者：
Zhou, Jianfang[1,2] * ; Qian, Chuanyun[3,4] ; Zhao, Mingyan[5] ; Yu, Xiangyou[6] ; Kang, Yan[7] ; Ma, Xiaochun[8] ; Ai, Yuhang[9] ; Xu, Yuan[10] ; Liu, Dexin[11] ; An, Youzhong[12] ; Wu, Dawei[13] ; Sun, Renhua[14] ; Li, Shusheng[15] ; Hu, Zhenjie[16] ; Cao, Xiangyuan[17] ; Zhou, Fachun[18] ; Jiang, Li[19] ; Lin, Jiandong[20] ; Mao, Enqiang[21] ; Qin, Tiehe[22] ; He, Zhenyang[23] ; Zhou, Lihua[24] ; Du, Bin[1,2] ;
单位： [1]Peking Union Med Coll Hosp, Peking Union Med Coll, Med ICU, Beijing 100021, Peoples R China [2]Chinese Acad Med Sci, Beijing 100730, Peoples R China [3]Kunming Med Univ, Affiliated Hosp 1, Dept Emergency Med, Kunming, Peoples R China [4]Kunming Med Univ, Affiliated Hosp 1, Med ICU, Kunming, Peoples R China [5]Harbin Med Univ, Dept Crit Care Med, Affiliated Hosp 1, Harbin, Peoples R China [6]Xinjiang Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Urumqi, Peoples R China [7]Sichuan Univ, Dept Crit Care Med, West China Hosp, Chengdu 610064, Peoples R China [8]China Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Shenyang, Peoples R China [9]Cent South Univ, Xiangya Hosp, Dept Crit Care Med, Changsha, Hunan, Peoples R China [10]Capital Med Univ, Beijing Tongren Hosp, Dept Crit Care Med, Beijing, Peoples R China [11]Jilin Univ, Dept Crit Care Med, Hosp 2, Changchun 130023, Peoples R China [12]Peking Univ, Peoples Hosp, Dept Crit Care Med, Beijing 100871, Peoples R China [13]Shandong Univ, Qilu Hosp, Dept Crit Care Med, Jinan 250100, Peoples R China [14]Zhejiang Prov Peoples Hosp, Dept Crit Care Med, Hangzhou, Zhejiang, Peoples R China [15]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Crit Care Med,Wuhan 430074,Peoples R China [16]Hebei Med Univ, Dept Crit Care Med, Hosp 4, Shijiazhuang, Peoples R China [17]Ningxia Med Univ, Gen Hosp, Dept Crit Care Med, Yinchuan, Peoples R China [18]Chongqing Med Univ, Affiliated Hosp 1, Dept Emergency & Intens Care Med, Chongqing, Peoples R China [19]Capital Med Univ, Fuxing Hosp, Dept Crit Care Med, Beijing, Peoples R China [20]Fujian Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Fuzhou, Peoples R China [21]Shanghai Jiao Tong Univ, Ruijin Hosp, Emergency ICU, Shanghai 200030, Peoples R China [22]Guangdong Gen Hosp, Dept Crit Care Med, Guangzhou, Guangdong, Peoples R China [23]Hainan Prov Peoples Hosp, Dept Crit Care Med, Haikou, Peoples R China [24]Inner Mongolia Med Univ, Affiliated Hosp, Dept Crit Care Med, Hohhot, Peoples R China
出处：
DOI： 10.1371/journal.pone.0107181
ISSN：

摘要：
Introduction: Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality. Methods: We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included. Results: A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027-1.109), presence of ARDS (OR, 2.676; 95% CI, 1.691-4.235), bloodstream infection (OR, 2.520; 95% CI, 1.142-5.564) and comorbidity of cancer (OR, 2.246; 95% CI, 1.141-4.420) were significantly associated with mortality. Conclusions: Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.

基金：
Capital Clinical Application Research grant from the Science and Technology Commission of Beijing [Z131107002213112]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类 | 2 区 生物
小类 | 2 区 综合性期刊
最新[2025]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
JCR分区：
出版当年[2012]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

第一作者：
第一作者单位： [1]Peking Union Med Coll Hosp, Peking Union Med Coll, Med ICU, Beijing 100021, Peoples R China [2]Chinese Acad Med Sci, Beijing 100730, Peoples R China
通讯作者：
通讯机构： [1]Peking Union Med Coll Hosp, Peking Union Med Coll, Med ICU, Beijing 100021, Peoples R China [2]Chinese Acad Med Sci, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Zhou Jianfang,Qian Chuanyun,Zhao Mingyan,et al.Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China[J].PLOS ONE.2014,9(9):doi:10.1371/journal.pone.0107181.
APA：
Zhou, Jianfang,Qian, Chuanyun,Zhao, Mingyan,Yu, Xiangyou,Kang, Yan...&Du, Bin.(2014).Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China.PLOS ONE,9,(9)
MLA：
Zhou, Jianfang,et al."Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China".PLOS ONE 9..9(2014)

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