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MicroRNA-152 targets ADAM17 to suppress NSCLC progression

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Cardiothorac Surg, Wuhan 430030, Hubei, Peoples R China

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关键词： Non-small cell lung cancer miR-152 ADAM metallopeptidase domain 17 Proliferation Migration Invasion

摘要：

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. In this study, we show that miR-152 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues and cell lines. Restoration of miR-152 significantly reduces proliferation, colony formation, migration and invasion of NSCLC cells. In addition, ADAM metallopeptidase domain 17 (ADAM17) is identified as a target of miR-152 in NSCLC cells, and miR-152-induced suppression of cell proliferation, colony formation, migration and invasion is partially mediated by silencing of ADAM17 expression. Furthermore, ADAM17 inversely correlates with miR-152 in NSCLC tissues. Collectively, our findings indicate that miR-152 acts as tumor suppressor in NSCLC partially via targeting ADAM17. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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出版当年[2013]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 3 区生物物理 4 区细胞生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2012]版：

Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3 最新[2023版] 3.8 最新五年平均 3.582 出版当年[2012版] 3.478 出版当年五年平均 3.538 出版前一年[2011版] 3.341 出版后一年[2013版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Cardiothorac Surg, Wuhan 430030, Hubei, Peoples R China

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