Interleukin-4 (IL-4) -524C > T polymorphism has been implicated to alter the risk of colorectal cancer (CRC), but the results are controversial. The objective of this study was to quantitatively evaluate the association between IL-4 -524C > T polymorphism and CRC risk. A comprehensive search was conducted to identify all eligible studies of IL-4 -524C > T polymorphism and CRC risk. Statistical analysis was performed with Review Manager 5.0 and Stata 11. A total of 5 case-control studies, including 1,224 cases and 1,551 controls, were included. The combined results based on all eligible studies suggested that IL-4 -524C > T polymorphism was not associated with CRC susceptibility. When stratifying for race, the data showed that the IL-4 -524C > T polymorphism was also not associated with an increased CRC susceptibility in Caucasians. Our study suggests that IL-4 -524C > T polymorphism may be not associated with an increased CRC susceptibility.
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Oncol,Wuhan 430030,Hubei Province,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Huanlei,Hu Jia,Liu Bo,et al.Lack of association between interleukin-4-524C>T polymorphism and colorectal cancer susceptibility[J].TUMOR BIOLOGY.2014,35(4):3657-3662.doi:10.1007/s13277-013-1484-6.
APA：
Wu, Huanlei,Hu, Jia,Liu, Bo,Tao, Yu,Zhou, Xiao&Yuan, Xianglin.(2014).Lack of association between interleukin-4-524C>T polymorphism and colorectal cancer susceptibility.TUMOR BIOLOGY,35,(4)
MLA：
Wu, Huanlei,et al."Lack of association between interleukin-4-524C>T polymorphism and colorectal cancer susceptibility".TUMOR BIOLOGY 35..4(2014):3657-3662
