Amphiphilic copolymers P(PBA)-g-P(PEG) containing poly(phenylboronic acid) (PPBA) and poly(ethylene glycol) (PEG) side chains were synthesized by copolymerization of 4-vinylphenylboronic acid (PBA) and poly(ethylene glycol) methyl ether methacrylate. The surface tension results showed that the critical micelle concentration (CMC) of P(PBA)-g-P(PEG) was 0.09g/L. TEM revealed that these copolymers self-assembled into regular sphere micelles above CMC. The photon correlation spectroscopy suggested that they had unique performance of thermo-induced self-assembly. Above critical micelle temperature, they self-assembled into monodisperse micelles with thermosensitivity. Hydrodynamic diameters of these micelles increased dramatically in the presence of glucose. The glucose-regulated drug release behavior was observed through UV-vis spectroscopy.
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Orthopaed Surg, Union Hosp, Wuhan 430074, Peoples R China
通讯作者：
通讯机构：[2]Hubei Univ, Hubei Prov Key Lab Ind Biotechnol, Fac Mat Sci & Engn, Key Lab Green Preparat & Applicat Funct Mat,Minis, Wuhan, Peoples R China[*1]Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Fac Mat Sci & Engn, Key Lab Green Preparat & Applicat Funct Mat,Minis, Wuhan, Peoples R China
推荐引用方式(GB/T 7714)：
Zheng Dong,An Yuan Yuan,Yang Shuhua,et al.Self-Assembled Glucose and Thermo Dual-Responsive Micelles of an Amphiphilic Graft Copolymer[J].INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS.2014,63(3):115-122.doi:10.1080/00914037.2013.769256.
APA：
Zheng, Dong,An, Yuan Yuan,Yang, Shuhua,Wu, Wei,Xu, Weihua...&Wu, Shuilin.(2014).Self-Assembled Glucose and Thermo Dual-Responsive Micelles of an Amphiphilic Graft Copolymer.INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,63,(3)
MLA：
Zheng, Dong,et al."Self-Assembled Glucose and Thermo Dual-Responsive Micelles of an Amphiphilic Graft Copolymer".INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS 63..3(2014):115-122
