单位：[1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China华中科技大学同济医学院附属同济医院肝脏外科外科学系
Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer. (C) 2014 Elsevier Inc. All rights reserved.
基金：
State Key Project on Infection Disease of China [2012ZX10002016-004, 2012ZX10002010-001-004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202300, 81372327]
第一作者单位：[1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
通讯作者：
通讯机构：[1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China[*1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, 430030 Wuhan, China
推荐引用方式(GB/T 7714)：
Zhang Zhan-Guo,Chen Wei-Xun,Wu Yan-Hui,et al.MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2014,454(1):109-114.doi:10.1016/j.bbrc.2014.10.049.
APA：
Zhang, Zhan-Guo,Chen, Wei-Xun,Wu, Yan-Hui,Liang, Hui-Fang&Zhang, Bi-Xiang.(2014).MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,454,(1)
MLA：
Zhang, Zhan-Guo,et al."MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 454..1(2014):109-114
