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Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes

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单位： [1]South Cent Univ Nationalities, Coll Biomed Engn, Lab Membrane Ion Channels & Med, Key Lab Cognit Sci,State Ethn Affairs Commiss, Wuhan 1231, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol, Tongji Med Coll, Wuhan 430074, Peoples R China

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关键词： age dorsal root ganglion HCN channels

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In rat's sensory neurons, hyperpolarization-activated inward currents (I-h) play an essential role in mediating action potentials and contributing to neuronal excitability. Classified by the size of neurons and ages, we studied the I-h and transcription levels of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels using electrophysiology and the single-cell RT-PCR. In voltage-clamp studies, I-h and half-maximal activation voltage (V-1/2) changed with age and size. An analysis of all HCN subtypes in dorsal root ganglion (DRG) neurons by single-cell RT-PCR was carried out. HCN1 and HCN3 in medium-small elderly neurons had a weak expression. HCN2 in newborns and HCN4 in elderly rats also had a weak expression. The aim of this study is to examine the age-related I-h and HCN channels subunits in different ages and sizes of DRG neurons. The results would be significant in understanding the physiological and pathophysiological function of different sizes of DRG neurons in different age periods. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2013]版：

Q4 NEUROSCIENCES

最新[2023]版：

Q4 NEUROSCIENCES

影响因子： 1.6 最新[2023版] 1.6 最新五年平均 1.644 出版当年[2013版] 1.817 出版当年五年平均 1.404 出版前一年[2012版] 1.52 出版后一年[2014版]

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第一作者单位： [1]South Cent Univ Nationalities, Coll Biomed Engn, Lab Membrane Ion Channels & Med, Key Lab Cognit Sci,State Ethn Affairs Commiss, Wuhan 1231, Hubei, Peoples R China

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